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oai:ginmu.naramed-u.ac.jp:10564/18442017-06-11T23:20:26Zhdl_10564_1843表紙、目次、投稿規定、奥付(Vol.44 No.1)表紙目次投稿規定奥付奈良医学会2011-12-20T00:48:59Z2011-12-20T00:48:59Z1993-02-28OtherOthers1702134 bytesapplication/pdf奈良医学雑誌 Vol.44 No.10469555013450069http://hdl.handle.net/10564/184404695550AN00180974奈良医学雑誌441jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/18452017-05-29T06:07:47Zhdl_10564_1843宗教上の理由で治療開始が遅延した経気管支散布性肺結核の一例A CASE OF PULMONARY TUBERCULOSIS WITH TRANSBRONCHIAL-SPREAD SHADOW ON CHEST ROENTGENOGRAM WITH THERAPY DELAYED DUE TO PATIENT'S RELIGIOUS PROBLEMS友田, 恒一長, 澄人古西, 満濱田, 薫塚口, 勝彦徳山, 猛米田, 尚弘成田, 亘啓pulmonary tuberculosisdiffuse fine nodular shadowpatient's delayA 29-year-old female was admitted complaints of dyspnea and high fever without therapy for abnormal shadow on chest roentgenogram during 8 months due to her religious problems. Because M. tuberculosis was detected, therapy for tuberculosis was indicated. After this therapy, widespread consolidation with diffuse fine nodular shadows on chest roentgenogram turned to multiple thin walled cavities with wide destruction of lung tissue. This advanced tuberculosis was thought to result mainly from the patient's delay.奈良医学会2011-12-20T00:56:44Z2011-12-20T00:56:44Z1993-02-28ArticleDepartmental Bulletin Paper972346 bytesapplication/pdf奈良医学雑誌 Vol.44 No.1 p.1-40469555013450069http://hdl.handle.net/10564/184504695550AN00180974奈良医学雑誌44114jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/18462017-06-11T23:20:26Zhdl_10564_1843USE-DEPENDENT BLOCK AND RECOVERY OF NA⁺ CHANNELS BY CLASS IC ANTIARRHYTHMIC DRUGS (FLECAINIDE AND ETHACIZIN) IN CANINE VENTRICULAR MUSCLESatoh, HiroyasuMatsui, KazunoriNakatani, ToshiakiNarushima, ItaruNakashima, Toshikatsuclass Ic antiarrhythmic drugsflecainideethacizinslow kineticuse-dependent blockElectrophysiological effects of flecainide and ethacizin (class Ic antiarrhythmic drugs) were examined using conventional microelectrode techniques. Flecainide significantly depressed the maximum rate of depolarization (⩒max) at 3x10⁻⁶M, and depolarized the resting potential (RP) at 10⁻⁵M, in a concentration-dependent manner. Ethacizin depressed ⩒max at 10⁻⁶M, and depolarized RP at 10⁻⁵M, significantly. However, both drugs did not affect the effective refractory period (ERP) nor the action potential duration (75% repolarization, APD₇₅). Both also had no effect on the action potential amplitude (APA). On the other hand, the drugs caused a use (or rate)-dependent block of ⩒max, and their time constants of onset of inhibition (at 3 Hz) were slow ; 6.3±1.2 msec (n=10) in the presence of flecainide (10⁻⁵M), and 6.0±1.6 msec (n=6) in the presence of ethacizin (10⁻⁵M). The time constants of the recovery were also so late : 12.2±2.5 sec (n=3) for flecainide (10⁻⁵M), and 27.1±13.3 sec (n=3) for ethacizin (2x10⁻⁶M), These results indicate that both antiarrhythmic drugs, flecainide and ethacizin, have no effect on APD₇₅ and ERP, but possess the characteristics for very slow kinetics of the use-dependent block and the recovery for fast Na⁺ channels of cardiac muscles. Ethacizin produces slower kinetics for the Na⁺ channels than flecainide.奈良医学会2011-12-20T03:28:50Z2011-12-20T03:28:50Z1993-02-28ArticleDepartmental Bulletin Paper719415 bytesapplication/pdf奈良医学雑誌 Vol.44 No.1 p.5-130469555013450069http://hdl.handle.net/10564/184604695550AN00180974奈良医学雑誌441513engpublisher
oai:ginmu.naramed-u.ac.jp:10564/18472017-05-29T06:08:02Zhdl_10564_1843糖尿病における動脈硬化性血管障害の臨床的特徴A DETAILED STUDY OF RELEVANT FACTORS FOR MACROANGIOPATHY IN DIABETES MELLITUS金内, 雅夫紀川, 伊敏西岡, 久之森本, 真弓石井, 健司川野, 貴弘石原, 京子中島, 靖夫西浦, 公章土肥, 和紘石川, 兵衞arteriosclerosis obliteranscerebro-vascular diseasediabetes mellitusischemic heart diseasemacroangiopathymicroangiopathynephropathyretinopathyThe major risk factors of diabetic macroangiopathy and the associations between macroangiopathy and microangiopathy were examined in a cross-sectional study by multi-factorial analysis. The study group comprised 544 diabetics admitted between 1982
and 1991, of whom 350 were fully available for analysis. Variables used in this analysis
included current age, age at onset, diabetes duration, obesity, hypertension, hyperlipidemia, ischemic heart disease (IHD), cerebro-vascular disease (CVD), arteriosclerosis obliterans (ASO), nephropathy, retinopathy and treatment modality. Results were as follows : (1) IHD was closely associated with onset at 50s and 60s, disease duration of 5 to 9 years, and oral agent ; (2) CVD was closely associated with aging, disease duration of 10 to 14 years, simple retinopathy, and oral agent ; (3) ASO was closely associated with disease duration of more than 15 years and persistent proteinuria.奈良医学会2011-12-20T03:55:17Z2011-12-20T03:55:17Z1993-02-28ArticleDepartmental Bulletin Paper1086224 bytesapplication/pdf奈良医学雑誌 Vol.44 No.1 p.14-230469555013450069http://hdl.handle.net/10564/184704695550AN00180974奈良医学雑誌4411423jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/18482017-05-29T06:07:47Zhdl_10564_1843アミノヌクレオシド腎症における腎糸球体および血小板膜陰性荷電の変化STUDY OF GLOMERULAR AND PLATELET ANINOIC SITES IN AMINONUCLEOSIDE NEPHROSIS上辻, 秀和山下, 隆司中島, 充岡島, 馨松永, 健司河原, 信吾aminonucleoside nephrosisglomerular anionic siteplateletIn aminonucleoside nephrosis (AN), which can be regarded as an experimental model of minimal change nephrotic syndrome (MCNS), ultrastructural alteration of glomerular anionic sites were studied using polyetyleneimine (PEI) as a cationic probe, and correlated with the change of platelet membrane negative charge. In control rats, PEI was seen in epithelial cell surface and in both lamina rara externa and lamina rara interna. On the other hand, AN rats, showed a loss of polyanion on the epithelial surface associated with foot process fusion and a reduction of anionic sites within glomerular basement membrane. The degree of anionic sites correlated with proteinuria. The negative charge of pletelet membrane also decreased in AN rats and correlated with a loss of glomerular anionic sites.
However, there was no remarkable change in platelet morphological findings on electron
microscopy. These findings may provide useful information on platelet function in pediatric MCNS.奈良医学会2011-12-20T07:26:43Z2011-12-20T07:26:43Z1993-02-28ArticleDepartmental Bulletin Paper964054 bytesapplication/pdf奈良医学雑誌 Vol.44 No.1 p.24-290469555013450069http://hdl.handle.net/10564/184804695550AN00180974奈良医学雑誌4412429jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/18492017-05-29T06:07:48Zhdl_10564_1843アンケート調査による幽門保存胃切除術の長期遠隔成績LONG-TERM FOLLOW-UP RESULT AFTER PYLORUS-PRESERVING GASTRIC RESECTION FOR GASTRIC ULCER BY A QUESTIONNAIRE松為, 泰介金泉, 年郁朴, 秀一石川, 博文清水, 良祐河嶌, 勝中野, 博重pylorus-preserving gastrectomy (PPG)questionnairesymptoms of dumpingA long-term follow-up study using a questionnaire was conducted in order
to assess clinical results of pylorus-preserving gastrectomy (PPG). Of 54 patients who underwent PPG, 45 patients followed for more than seven years were analyzed in the late postoperative state. These patients were compared with patients who underwent Billroth Ⅰ resection (BⅠ) by their responses to datailed questionnaires. Through the long-term follow-up results, PPG was found to be similar to BⅠ with regard to social life, meal intake, sense of abdominal pressure, heartburn sensation, recurrence rate and satisfaction rate, but
superior to BⅠ with regard to gain of body weight, nausea, diarrhea and symptoms of dumping. The results suggest that PPG is worthy of trial as a surgical treatment of gastric ulcer.奈良医学会2011-12-21T01:29:50Z2011-12-21T01:29:50Z1993-02-28ArticleDepartmental Bulletin Paper576910 bytesapplication/pdf奈良医学雑誌 Vol.44 No.1 p.30-360469555013450069http://hdl.handle.net/10564/184904695550AN00180974奈良医学雑誌4413036jpnpublisher