2024-03-29T15:34:27Zhttp://ginmu.naramed-u.ac.jp/dspace-oai/request
oai:ginmu.naramed-u.ac.jp:10564/17992017-06-11T23:20:26Zhdl_10564_1798表紙、目次、投稿規定、奥付(Vol.44 No.3)表紙目次投稿規定奥付奈良医学会2011-12-09T05:44:06Z2011-12-09T05:44:06Z1993-06-30OtherOthers1800831 bytesapplication/pdf奈良医学雑誌 Vol.44 No.30469555013450069http://hdl.handle.net/10564/179904695550AN00180974奈良医学雑誌443jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/18002017-05-29T06:08:01Zhdl_10564_1798抗原特異的B細胞を用いた抗原提示に関する基礎的研究ANALYSIS OF ANTIGEN PRESENTATION TO ANTIGEN SPECIFIC T CELLS USING B LYMPHOMA CELLS SPECIFIC FOR DEFINED ANTIGEN吉川, 正英北神, 敬司松村, 圭祐福井, 博石坂, 重昭辻井, 正穂積, 信道antigen presentationhelper T cellantigen specific B cellIL-2 productioncytotoxicityWe have studied the function of antigen specific immunoglobulin (Ig) receptors in antigen presentation. Monoclonal B cell lines expressing antigen specific surface IgM, IgD or IgG were established by transferring the gene encoding heavy (μ, δ or
γ) and light (κ) chains specific for the hapten 2, 4, 6-trinitropheny (TNP) into Ⅰa bearing B cell lymphoma A 20-2 J and WEHI 279 lines. Transfectants were compared in a quantitative assay for the ability to present TNP-carrier to carrier-specific T helper (Th) cells. The A 20-2 J-derived transfectants expressing μκтɴр, δκтɴр or γκтɴр had similiar amounts of the TNP-specific idiotype on their surface and showed an equal capacity to present antigen, which was about 1000-fold more efficient than that of the parental line. However, the γκтɴр transfectant of WEHI 279 line expressed lower amounts of the idiotype than μκтɴр or δκтɴр transfectant and exhibited a decreased capacity of antigen presentation. It was suggested that the antigen presenting capacity of antigen-specific B cells depends on the amount of the idiotype expressed, regardless of its Ig isotype. In addition, a Th hybridoma line used in this study exhibited cytotoxic activity to antigen presenting cell as well as IL-2 production when it was activated. Interestingly, cytotoxicities were also found to NK-resistant cells and to human tumor cells. The target recognition of Th cells was supposed to be different from that of NK cells or cytotoxic T cells.奈良医学会2011-12-09T07:10:04Z2011-12-09T07:10:04Z1993-06-30ArticleDepartmental Bulletin Paper723743 bytesapplication/pdf奈良医学雑誌 Vol.44 No.3 p.137-1450469555013450069http://hdl.handle.net/10564/180004695550AN00180974奈良医学雑誌444137145jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/18012017-06-11T23:20:26Zhdl_10564_1798腋窩に発生したSolid-cystic hidradenomaの一症例A CASE OF SOLID-CYSTIC HIDRADENOMA OCCURRING ON THE AXILLA小林, 永策辻内, 俊文堤, 雅弘遠藤, 武弘堀口, 浩資小西, 陽一白井, 利彦西嶋, 義信hidradenomaaxillaA case of solid-cystic hidradenoma occurring on the left axilla of an 11-year-old girl is reported. The tumor was hemispherical, covered with nomal skin, and movable to the underlying tissue. Histopathologically the tumor was revealed to be localized in subcutaneous fat tissue and surrounded with thin fibrous connective tissue. The tumor cells consisted of epidermoid cells and clear cells, although the former were dominant. Many tubular structures containing colloidal substance were observed within the tumor.奈良医学会2011-12-12T04:24:02Z2011-12-12T04:24:02Z1993-06-30ArticleDepartmental Bulletin Paper392277 bytesapplication/pdf奈良医学雑誌 Vol.44 No.3 p.146-1480469555013450069http://hdl.handle.net/10564/180104695550AN00180974奈良医学雑誌443146148jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/18022017-05-29T06:07:43Zhdl_10564_1798奈良県立医大精神科児童思春期外来における不登校の現況と登校拒否の予後因子THE CURRENT SITUATION IN REGARD TO NON-ATTENDANCE AT SCHOOL AND PROGNOSTIC FACTORS OF SCHOOL REFUSAL IN CHILD AND ADOLESCENT CLINIC OF DEPARTMENT OF PSYCHIATRY AT NARA MEDICAL UNIVERSITY飯田, 順三岩坂, 英巳平尾, 文雄川端, 洋子松山, 光晴田原, 宏一橋野, 健一松村, 一矢青山, 富貴子崎山, 忍辻本, 博一井川, 玄朗non-attendance at schoolmental disorderschool refusalprognostic factorA study on prognostic factors of non-attendance, especially school refusal in the strict sense was conducted. 114 out-patients (male 63, female 51) visiting the Child and Adolescent Clinic of the Department of Psychiatry at Nara Medical University were
studied. The results were : (1) The patients consisted of 17 students of elementary school (14.9%), 46 of junior high school (40.4%) and 51 of high school (44.7%). (2) School refusal in the strict sense was 51.8%. In the rest, non-attendance at school
was based on mental disorders including schizophrenia (14.9%), depression (6.1%), and
anthropophobia (6.1%). (3) As to onset of school refusal, many cases began in September, April and May. Premorbid personality tended to be introverted, perfectionisitc, sensitive and obstinate.
Psychiatric hereditary factors were found in 24.5% of all cases, and antipsychotics were
administered to 45.8% of all cases. (4) In regard to the differences between the good prognostic group and poor prognostic group, grade, trigger and the number of times of consultation were significant.奈良医学会2011-12-12T04:42:56Z2011-12-12T04:42:56Z1993-06-30ArticleDepartmental Bulletin Paper737616 bytesapplication/pdf奈良医学雑誌 Vol.44 No.3 p.149-1550469555013450069http://hdl.handle.net/10564/180204695550AN00180974奈良医学雑誌443149155jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/18032017-05-29T06:07:44Zhdl_10564_1798ラット腎腫瘍発生におけるリン酸塩の促進作用並びにクエン酸カリウムの抑制効果に関する研究A STUDY OF MODULATION BY PHOSPHATE SALTS AND POTASSIUM CITRATE ON RAT RENAL TUMORIGENESIS西井, 清治phosphate saltpromotioninhibitionrenal tumorigenesisMedium organ bioassays to shorten the experimental duration with unilateral nephrectomy for early detection of renal tumors were investigated in male Wistar rats
after N-ethyl-N-hydroxyethylnitrosamine (EHEN) administration. Animals were fed 1000 ppm EHEN diet for 2 weeks and the left kidney was removed at week 3. They received several promoting agents and non-promoting agents as negative control for 18 weeks. Within a relatively short period of 20 weeks, the promoting effect on rat renal
tumorigenesis can be detected as a significant increase of preneoplastic lesions, such as simple or adenomatous hyperplasias with increased levels of 5-bromo-2'-deoxyuridine (BrdU)-labeled renal cortical tubular epithelia. Various kinds of salts and metals contained in the diet were tested at concentrations more than 20 times the normal doses in a preliminary experiment for nephrotoxicity over 8 weeks. Potassium dibasic phosphate (PDP), potassium aluminum sulfate (PAS) and copper sulfate (CS) induced nephropathy. Therefore, these three salts were investigated in this medium-term bioassay for renal tumorigenesis. Treatment with 5% PDP induced renal calcification with severe nephropathy and promoted the development of preneoplastic lesions, but that with 5% PAS or 0.5% CS did not. To study the effect of alkalization on renal mineralization,animals concomitantly received 5% potassium citrate (PC). The addition of PC to PDP diet reduced the promoting effect on renal tumorigenesis ; also indicated was retardation of renal calcium by histology, serum biochemistry and
urinalysis. The promoting effects of PDP and inhibitory effects of PC were correlated to
BrdU-labeling indices. Immunohistochemical study was used to examine α₂ᵤ-globulin
accumulation ; however, PDP-induced nephropathy did not appear to be related to α₂ᵤ globlin, as evidenced by the negative results. A pathogenesis for renal carcinogenesis is suggested in which nephropathy associated with mineralization enhanced the development of renal cell tumors.奈良医学会2011-12-12T05:25:16Z2011-12-12T05:25:16Z1993-06-30ArticleDepartmental Bulletin Paper2007835 bytesapplication/pdf奈良医学雑誌 Vol.44 No.3 p.156-1670469555013450069http://hdl.handle.net/10564/180304695550AN00180974奈良医学雑誌443156167jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/18132017-05-29T06:07:46Zhdl_10564_1798四国出土頭骨の古人類学的研究PALEOANTHROPOLOGICAL STUDIES ON SKULLS EXCAVATED FROM SHIKOKU山田, 正和paleoanthropologycraniometryprehistoric periodancestor JapaneseSkulls excavated in Shikoku were studied craniometrically and arranged by their localities in Century order from the Jomon to the historic period. There were 13 individuals of Tokushima, 2 of Kagawa and 16 of Ehime. Half of them were reconstructed and their physical characteristics were effectively compared by indices such as cranial index, upper-facial indices, nasal index and upper alveolar arch typing. The results were compared with those of modern skulls of the Kinki district. The Tokushima's skulls were most dolichocephalic and the others were mesocephalic. The upper faces were mostly low and wide, and the nasal index showed generally a wide type. Local differences and varieties in relating to the era were found even in Shikoku. The characteristics seem very different from those of the modern skulls of the Kinki
district. From the present craniometrical basis of differences in physical characteristics, the Shikoku ancestors appear to be more independent of neighbouring immigrants and slower to mix with immigrants than the inhabitants of the Kinki district.奈良医学会2011-12-13T05:23:39Z2011-12-13T05:23:39Z1993-06-30ArticleDepartmental Bulletin Paper1505461 bytesapplication/pdf奈良医学雑誌 Vol.44 No.3 p.168-1840469555013450069http://hdl.handle.net/10564/181304695550AN00180974奈良医学雑誌443168184jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/18142017-06-11T23:20:26Zhdl_10564_1798A CASE OF DIABETES INSIPIDUS ACCOMPANYING THIRST DISORDER ASSOCIATED WITH HYPEROSMOLAR DIABETIC COMAOkamoto, ShingoKamata, OsamuMatsumoto, MasamiIzumi, YukikoNishiyama, ToshimasaFukui, HiroshiTsujii, TadasuSakaki, Toshisukehyperosmolar diabetic comadehydrationThe case of a 14-year-old female who suffered from hyperosmolar diabetic coma (HODC) after resection of craniopharyngioma and during treatment for hypopituitarism
and diabetes insipidus is presented. In Aug. 1989, craniopharyngioma was diagnosed and she underwent resection surgery and radiotherapy. Since then, she had been on
supplemental therapy with hydrocortisone and thyroxin and desmopressin (DDAVP). On Jan. 17, 1992, she fell into HODC upon ingesting a large amount of soft drink to supplement
water due to persistent polyuria. She improved quickly when supplementary fluids and insulin were administered. She had demonstrated no abnormality in glucose tolerance prior to this manifestation. Insulin therapy was deemed unnecessary after her recovery from HODC. Because of a disorder in the central nervous thirst mechaninm, she lacked the sense of thirst and concomitantly the thirst-mediated water intake in spite of elevated plasma osmolarity due to dehydration and hyperglycemia. This seemed to be the cause of her accelerating dehydration. The resulting insulin resistance then brought about her HODC. Thus, it is difficult to consider such a case of HODC as symptomatic of diabetes when no abnormality in glucose tolerance either before manifestation or after restoration can be found. It should rather be considered as a case of “dehydration hyperglycemia" and be
treated as such.奈良医学会2011-12-13T05:58:22Z2011-12-13T05:58:22Z1993-06-30ArticleDepartmental Bulletin Paper781273 bytesapplication/pdf奈良医学雑誌 Vol.44 No.3 p.185-1910469555013450069http://hdl.handle.net/10564/181404695550AN00180974奈良医学雑誌443185191engpublisher
oai:ginmu.naramed-u.ac.jp:10564/18222017-05-29T06:07:46Zhdl_10564_1798ネズミチフス症における免疫成立機序に関する研究ANALYSIS OF VACCINE EFFECT TO THE INFECTION OF SALMONELLA TYPHIMURIUM IN OUTBRED MICE安井, 潔crude ribosomal fraction (CRF)transfer RNAnon-O antigenprotective antibodycell-mediated resistanceTwo outbred mouse strains, ddY and CF1, were tested for their ability to be protected against infection with Salmonella typhimurium by several types of salmonella
vaccines. These strains have the same levels of innate susceptibility to S. typhimurium, and also have the same capacity to develop delayed-type hypersensitivity (DTH) to salmonella antigens. Both the crude ribosomal fraction (CRF) and live-cell vaccines conferred acquired resistance on both strains, characterized by greater responses of T cells to salmonella antigens. Mice of the ddY strain were also protected by the purified transfer RNA (tRNA) vaccine, which was free of O antigens, but CF1 mice were not, despite the presence of T-cell reactivity with salmonella antigens. Neither strain was protected by phenol-water-extracted lipopolysaccharide (LPS). The tRNA-immunized CF1 mice were protected by transfer of antiserum to CRF, but not by transfer of anti-LPS antibody. This antiserum to CRF, however, did not transfer acquired resistance into non-immune mice of
either strain. These observations suggest that CF1 mice may require an antibody to another non-O antigen existing in CRF to develop acquired resistance, and that stimulation of the defense system by tRNA may be essential to the development of acquired resistance in CF1 mice. The active component in CRF of Salmonella typhimurium, capable of inducing protective antibody, was partially purified by two series of chromatography (Sephadex G-150 and DEAE-Sepharose CL 6B) after sodium dodecyl sulphate (SDS)-treated CRF was precipitated with ammonium sulphate. The major active component was eluted by 0.4-0.45 M Nacl from DEAE-Sepharose CL 6B, and its molecular weight was 43,000 as determined by SDS-polyacrylamide gel electrophoresis. Immunization with the fraction containing
43,000 component alone did not always confer protection on CF1 mice, but its administration together with either the purified tRNA or Freund's complate adjuvant (FCS) was much more effective against infection with S. typhimurium. Western blot analysis showed that 43,000 component did not react to ansiserum to LPS, but to antiserum to CRF. The antibody elicited by non-O antigenic component and the cell-mediated resistance stimulated by the adjuvant effect of RNA together confer effective protection on CF1 mice.奈良医学会2011-12-13T07:21:05Z2011-12-13T07:21:05Z1993-06-30ArticleDepartmental Bulletin Paper1266080 bytesapplication/pdf奈良医学雑誌 Vol.44 No.3 p.192-2020469555013450069http://hdl.handle.net/10564/182204695550AN00180974奈良医学雑誌443192202jpnpublisher