2024-03-29T08:07:25Zhttp://ginmu.naramed-u.ac.jp/dspace-oai/request
oai:ginmu.naramed-u.ac.jp:10564/2432017-06-11T23:20:26Zhdl_10564_1566表紙、目次、投稿規定、奥付(Vol.55 No.4-5)表紙目次投稿規定奥付奈良医学会奈良県立医科大学2008-06-30T07:24:10Z2008-06-30T07:24:10Z2004-10-31OtherOthers2295372 bytesapplication/pdfJournal of Nara Medical Association Vol.55 No.4-513450069http://hdl.handle.net/10564/24313450069AA11252383Journal of Nara Medical Association554-5jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/2442017-05-29T06:07:05Zhdl_10564_1566脳腫瘍における遺伝子変異の解析GENETIC ALTERATIONS IN BRAIN TUMORS中村, 光利小西, 登榊, 寿右primary glioblastomsecondary glioblastomaoligodendrogliomadiffuse astrocytoma多形性膠芽腫(glioblastoma, WHO grade Ⅳ)の発生には臨床経過並びにp53, EGFR
等の遺伝子異常の検索から,de novoに発生するprimary glioblastoma(WHO grade Ⅳ)と,
星状細胞腫(diffuse astrocytoma, WHO grade Ⅱ)や退形成星状細胞腫(anaplastic
astrocytoma, WHO grade Ⅲ)から悪性転化してsecondary glioblastoma(WHO grade Ⅳ)に
至る2通りの経路があることが明らかとなってきた。著者らはprimary glioblastomaと
secondary glioblastomaにおける既知および未知の遺伝子変異をジェネティックおよびエピ
ジェネティックの両面から解析し,形態的には類似した多形性膠芽腫であっても,その原因遺
伝子は異なったものであることを立証してきた。また,diffuse astrocytomaと乏突起神経膠腫
(oligodendroglioma, WHO grade Ⅱ)との鑑別や,神経膠腫(glioma)の中での悪性度の評価な
ど組織形態学だけでなく,遺伝子解析による分子病理学的な観点からその発生メカニズムの検
討と治療への応用をめざし多くの報告がなされてきている。これらgliomaを中心とする脳腫瘍
において,我々がこれまで検索してきた遺伝子変化を紹介するとともに,脳腫瘍の発生や悪性
転化,再発においてどのようにこれらの遺伝子変異が関わるのか,臨床病理学的な側面を加え
て検討した。奈良医学会奈良県立医科大学2008-07-01T01:46:54Z2008-07-01T01:46:54Z2004-10-31ArticleDepartmental Bulletin Paper809558 bytesapplication/pdfJournal of Nara Medical Association Vol.55 No.4-5 p.205-21113450069http://hdl.handle.net/10564/24413450069AA11252383Journal of Nara Medical Association554-5205211jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/2452017-06-11T23:20:26Zhdl_10564_1566ANTI-HTLV-I p19 SUPPRESSES HTLV-I AG EXPRESSION IN PERIPHERAL BLOOD LYMPHOCYTES FROM HTLV-I CARRJERSAndo, YoshiyaMatsumoto, YosmnariKakimoto, KazuhiroMaruya, ChiakiEnomoto, MasahiroMatsuda, TetsunoriHTLV-Iantigenanti-p19anti-gp46Anti-HTLV-I antibodies possess an inhibitory action for HTLV-I infection.
In cases where cells persistently expressing HTLV-I antigen are the source of infection
m an in vitro system, antibodies against HTLV-I env antigens (such as anti-HTLV-I
gp46 175-199 antibody, etc.) have an inhibitory action for HTLV-I cell to cell infection. Our
examination of this inhibitory action for HTLV-I infection in peripheral blood
lymphocytes from HTLV-I carriers, who did not express antigens, revealed that anti-
HTLV-I p19 1OO-130 antibody inhibit infection by suppressing the expression of HTLV-I
antlgens.奈良医学会奈良県立医科大学2008-07-01T01:52:39Z2008-07-01T01:52:39Z2004-10-31ArticleDepartmental Bulletin Paper581379 bytesapplication/pdfJournal of Nara Medical Association Vol.55 No.4-5 p.213-21913450069http://hdl.handle.net/10564/24513450069AA11252383Journal of Nara Medical Association554-5213219engpublisher
oai:ginmu.naramed-u.ac.jp:10564/2462018-03-12T16:30:06Zhdl_10564_1566POSITION OF AXIS FOR ROTATION AT THE INTERVERTEBRAL JOINT IN RATSTohno, YoshiyukiTohzno, SetsukoAzuma, ChoMoriwake, YumiIntervertebral jointspinevertebraratTo elucidate whether the position of axis for rotation at the intervertebral
joint is related to the spinal curvature, the authors investigated the spinal columns of
rats. The spinal column of the rat was composed of 7 cervical, 13 thoracic, 6 lumbar, 4
sacral, and 27 coccygeal vertebrae. It was observed that the position of axis for rotation
at the intervertebral joint was shifted on the superior and inferior views of the 2nd
thoracic vertebra and was next shifted on the superior and inferior views of the 10th
thoracic vertebra. X-ray examination demonstrated that lordosis was seen in the
cervical and lower 1umbar (L4-L6) spine, whereas kyphosis was seen in the thoracic and
upper lumbar (Ll-L3) spine. The present study did not support the possibility that the
position of axis for rotation at the intervertebral joint was dorsal in the spinal site of
lordosis, whereas it was ventral in the spinal site of kyphosis.奈良医学会奈良県立医科大学2008-07-01T01:57:02Z2008-07-01T01:57:02Z2004-10-31ArticleDepartmental Bulletin Paper4792484 bytesapplication/pdfJournal of Nara Medical Association Vol.55 No.4-5 p.221-22613450069http://hdl.handle.net/10564/24613450069AA11252383Journal of Nara Medical Association554-5221226engpublisher
oai:ginmu.naramed-u.ac.jp:10564/2472017-05-29T06:07:16Zhdl_10564_1566実験的アレルギー性脳脊髄炎に対するPhosphodiesterase Inhibitorの抑制効果EFFECTS OF COMBINED THERAPY OF PHOSPHODIESTERASE INHIBITORS ON EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS田丸, 司experimental allergic encephalomyelitisphosphodiesterase inhibitormultiple sclerosisThe effects of combined therapy of subtypes of phosphodiesterase
inhibitors (PDEIs), which can inhibit the production of TNFα, were studied in rats with
actively induced experirnental allergic encephalomyelitis (EAE) by myelin basic protein.
The rats with EAE were treated with a single PDEI or the combination of two or three
PDEIs (amrinone: type3 PDEI,50mg/kg/day, papaverin HCl:non-specific type,
20mg/kg/day, and dipyridamole,50mg/kg/day). Each agent or the combination was
injected throughout days 1-10 or days 1-21 or days 8-21(only three PDEIs). In the group
treated with three PDEIs for days 1-21, the incidence of the disease was less than half
and the clinical score was significantly decreased compared to the control group treated
with normal saline. The other groups treated with one or two PDEIs were partially
effective. On pathological examination, mononuclear cell infiltration in the spinal cord
was decreased in the most effective group. The mRNA expression of TNFα by the
RT-PCR method in peripheral blood cells and spinal cord was decreased in the group
treated with three PDEIs. This study suggests that the combination therapy of three
subtypes of PDEIs is effective in the treatment of EAE in the rat and the combination
therapy of PDEIs rnay be of benefit in the treatment of multiple sclerosis.奈良医学会奈良県立医科大学2008-07-01T02:01:49Z2008-07-01T02:01:49Z2004-10-31ArticleDepartmental Bulletin Paper7269276 bytesapplication/pdfJournal of Nara Medical Association Vol.55 No.4-5 p.227-23613450069http://hdl.handle.net/10564/24713450069AA11252383Journal of Nara Medical Association554-5227236jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/2482018-03-12T16:30:08Zhdl_10564_1566銅キレート剤トリエンチンの抗血管新生作用と肝癌発育および肝発癌抑制効果の検討THE INHIBITORY EFFECT OF COPPER-CHELATOR, TRIENTINE, ON LIVER TUMOR GROWTH AND ON HEPATOCARCINOGENESIS BY ANGIOGENESIS SUPPRESSION吉井, 純一coppertrientineangiogenesishepatocellular carcinomaAngiogenesis is now recognized to play a pivotal role in tumor
development, and even in the process of carcinogenesis. Trientine dihydrochloride
(trientine) is used in clinical practice as a copper (Cu)-chelating agent. In this study, we
elucidate that the effect of trientine on tumor development and carcinogenesis is due to
the suppression of angiogenesis in the murine hepatocellular carcinoma cell (HCC)
xenograft model and in the rat hepatocarcinogenesis model, respectively. Trientine
suppressed the tumor development associated with suppression of intra-tumoral
angiogenesis. Trientine treatment also resulted in a marked increase of apoptosis in the
tumor, although tumor cell proliferation itself was not altered. In vitro studies also
showed that trientine is not cytotoxic for the tumor cells, but it significantly suppressed
the endothelial cell proliferation. In a diethylnitrosamine (DEN)-induced rat
hepatocarcinogenesis model, trientine treatment significantly suppressed glutathione
S-transferase placental form (GST-P)-positive preneoplastic lesions. Trientine also
markedly suppressed neovascularization in the liver to a similar level as that of
development of preneoplastic lesions. On the contrary, the intrahepatic cell proliferation
was not altered with or without trientine treatment. These results suggested that Cu
plays a pivotal role in HCC tumor development and carcinogenesis via angiogenesis
suppression. Since trientine is already used in clinical practice without any serious side
effects, it may be an effective new strategy for future HCC therapy.奈良医学会奈良県立医科大学2008-07-01T02:07:04Z2008-07-01T02:07:04Z2004-10-31ArticleDepartmental Bulletin Paper2463893 bytesapplication/pdfJournal of Nara Medical Association Vol.55 No.4-5 p.237-24813450069http://hdl.handle.net/10564/24813450069AA11252383Journal of Nara Medical Association554-5237248jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/2492018-04-18T16:30:06Zhdl_10564_1566小児胆道拡張症に対するMRCPの有用性と問題点EFFICACY AND PROBLEMS OF MRCP IN PEDIATRIC PATIENTS WITH CHOLEDOCHALCYSTS鹿子木, 英毅金廣, 裕道岡山, 順司高, 済峯中島, 祥介北野, 悟廣橋, 伸治豊坂, 昭弘Choledocal cystPediatric patientsMRCPPancreatobiliary maljunctionEvaluation of biliary anatomy and arrangement of the pancreatobiliary
maljunction is critically important in patients with choledochal cysts before surgical
therapy. Although endoscopic retrograde cholangio-pancreatography (ERCP) has been a
golden standard for preoperative evaluation of choledochal cysts, there are some
difficulties in performing this method in pediatric patients due to its invasiveness.
Recently, magnetic resonance cholangiopancreaticography (MRCP) was developed and has
been established as a less invasive diagnostic modality for the pancreatobiliary duct
system. We applied MRCP for ten pediatric patients with choledochal cysts. The bile
duct system was successfully visualized in all cases. Irnages of pancreatobiliary
maljunction were provided from MRCP in 5 of 9 patients who underwent MRCP before
operation. In conclusion, MRCP is a less invasive and quite useful diagnostic modality
for imaging of the pancreatobiliary duct system in pediatric patients with choledochal
cysts.奈良医学会奈良県立医科大学2008-07-01T02:15:41Z2008-07-01T02:15:41Z2004-10-31ArticleDepartmental Bulletin Paper4989963 bytesapplication/pdfJournal of Nara Medical Association Vol.55 No.4-5 p.249-25513450069http://hdl.handle.net/10564/24913450069AA11252383Journal of Nara Medical Association554-5249255jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/2502018-04-26T16:30:06Zhdl_10564_1566SHIFT OF AXIAL POSITION FOR ROTATION AT THE INTERVERTEBRAL JOINT IN DOGSTohno, YoshiyukiTohno, SetsukoAzuma, ChoMoriwake, YumiKumai, TsukasaYamada, GenIntervertebral jointspinevertebradogTo elucidate whether the position of axis for rotation at the intervertebral
joint is related with the spinal curvature, the authors investigated the spinal columns of
beagles. The spinal column of beagle was composed of 7 cervical, 13 thoracic, 7 lumbar,
3 sacral, and 19 coccygeal vertebrae. It was observed that the position of axis for
rotation at the intervertebral joint was shifted on the superior and inferior views of the
2nd thoracic vertebra and was next shifted on the superior and inferior views of the 10th
thoracic vertebra. It was suggested that in the case of beagle and Wistar rat with 13
thoracic vertebrae, the upper shift of axial position for rotation at the intervertebral joint
occurred on the superior and inferior views of the 2nd thoracic vertebra and the lower
shift of axial position for rotation at the intervertebral joint occurred on the superior and
inferior views of the 10th thoracic vertebra.奈良医学会奈良県立医科大学2008-07-01T02:21:38Z2008-07-01T02:21:38Z2004-10-31ArticleDepartmental Bulletin Paper6861412 bytesapplication/pdfJournal of Nara Medical Association Vol.55 No.4-5 p.257-26213450069http://hdl.handle.net/10564/25013450069AA11252383Journal of Nara Medical Association554-5257262engpublisher
oai:ginmu.naramed-u.ac.jp:10564/2512018-04-26T16:30:07Zhdl_10564_1566食道表在癌放射線治療著効後に照射野内に発見され内視鏡的治療で根治しえた食道粘膜癌の3例THREE CASES OF THE MUCOSAL ESOPHAGEAL CANCER DISCOVERED WITHIN THE IRRADIATED FIELD OF PREVIOUS RADIOTHERAPY FOR SUPERFICIAL ESOPHAGEAL CANCER AND TREATED SUCCESSFULLY WITH ENDOSCOPIC MUCOSAL RESECTION (EMR) AND LOCAL HEATING THERAPY浅川, 勇雄玉本, 哲郎吉村, 均松尾, 祥弘伊藤, 高広中西, 攝子城根, 憲久鎌田, 喜代志esophageal cancerradiotherapysalvage EMZRIn general, salvage EMIR after radiotherapy (RT) is regarded as contra-
indicated in esophageal cancer. We report here three cases of mucosal esophageal cancer
found within the irradiated field of previous RT and treated successfu11y with EMR and
local heating therapy.
Case 1, a 73-year-old man, was diagnosed with operable squamous cell carcinomas
(SCCs) of the esophagus (T1bN0M0: stage I). We performed radical radiotherapy (RT) of
70 Gy and the responses of these tumors were complete response (CR). Twenty-four
months after RT, we found metachronous mucosal esophageal cancer within the irradiated
field. Case 2, a 57-year-old man, was diagnosed with SCCs of the esophagus (T1aN0M0:
stage 0). We tried to perform endoscopic mucosal resection (EMR) for the tumors, but
could not resect them completely. Then, we performed additional RT of 60 Gy for the
residual tumors. The tumor responses were CR. Twenty months after RT, we found
recurrent mucosal esophageal cancer. Case 3, an 81-year-old man, was diagnosed with
SCC of the esophagus (T1bN0M0: stage I). We performed radical RT of 60 Gy because of
his advanced age, and the tumor response was CR. But 6 months after RT, we found
recurrent mucosal esophageal cancer. For these mmors, we performed EMR and local
heating therapy.
In conclusion, these endoscopic treatments may be useful in patients with mucosal
esophageal cancer within the irradiated field.奈良医学会奈良県立医科大学2008-07-01T02:26:24Z2008-07-01T02:26:24Z2004-10-31ArticleDepartmental Bulletin Paper15803309 bytesapplication/pdfJournal of Nara Medical Association Vol.55 No.4-5 p.263-26913450069http://hdl.handle.net/10564/25113450069AA11252383Journal of Nara Medical Association554-5263269jpnpublisher