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oai:ginmu.naramed-u.ac.jp:10564/3192017-06-11T23:20:26Zhdl_10564_1561表紙、目次、総目次、投稿規程詳細、奥付(Vol.58 No.5-6)表紙目次総目次投稿規程詳細奥付奈良医学会奈良県立医科大学OtherOthersapplication/pdfJournal of Nara Medical Association Vol.58 No.5-613450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/319Journal of Nara Medical Association, 58(5-6)http://hdl.handle.net/10564/319http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/319/1/000p.%e8%a1%a8%e7%b4%99%e3%80%81%e7%9b%ae%e6%ac%a1%e3%80%81%e7%b7%8f%e7%9b%ae%e6%ac%a1%e3%80%81%e6%8a%95%e7%a8%bf%e8%a6%8f%e7%a8%8b%e8%a9%b3%e7%b4%b0%e3%80%81%e5%a5%a5%e4%bb%98%28Vol.58_No.5-6%29.pdf13450069AA11252383Journal of Nara Medical Association585-62007-12-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/3202017-05-29T06:07:14Zhdl_10564_1561網膜視蓋投射系におけるトポグラフィックな神経結合形成の分子機構MOLECULAR MECHANISMS UNDERLYING THE FORMATION OF THE TOPOGRAPHIC RETINOTECTAL PROJECTION高橋, 弘雄坪井, 昭夫topographic projectionretinotectal projectionaxon guidanceregional specification特定領域の神経細胞集団が,互いの二次元的な相対的位置関係を保った状態で標
的領域の神経細胞集団と神経結合を形成するトポグラフィックな投射は,神経回路網の形成に
おける基本様式の一つである。トポグラフィックな投射の形成メカニズムについては,これま
で網膜視蓋投射系を用いて盛んにその研究がなされてきた。網膜においては発生の早い時期か
ら,様々な分子が前後軸および背腹軸に沿って領域特異的に発現し,相互作用しながらその領
域特異性を形作っている。この網膜内の領域特異化が基盤となり,直接的に標的領域の識別に
関わる軸索ガイダンス分子の発現が制御され,視神経のトポグラフィックな投射が形成される。
本稿では,網膜視蓋投射系の解析より得られた,トポグラフィックな投射形成のメカニズムに
関する知見を概説する。奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.58 No.5-6 p.147-15413450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/320Journal of Nara Medical Association, 58(5-6): 147-154http://hdl.handle.net/10564/320http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/320/1/147-154p.%e7%b6%b2%e8%86%9c%e8%a6%96%e8%93%8b%e6%8a%95%e5%b0%84%e7%b3%bb%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%88%e3%83%9d%e3%82%b0%e3%83%a9%e3%83%95%e3%82%a3%e3%83%83%e3%82%af%e3%81%aa%e7%a5%9e%e7%b5%8c%e7%b5%90%e5%90%88%e5%bd%a2%e6%88%90%e3%81%ae%e5%88%86%e5%ad%90%e6%a9%9f%e6%a7%8b.pdf13450069AA11252383Journal of Nara Medical Association585-61471542007-12-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/3212017-05-29T06:07:14Zhdl_10564_1561脳血管障害における経頭蓋超音波検査TRANSCRANIAL COLOR-CODED FLOW SONOGRAPHY IN ASSESSMENT OF STROKE PATIENTS斉藤, こずえ上野, 聡transcranial color-coded flow sonographysubarachnoid hemorrhagevasospasmmoyamoya diseasehighintensity transient signals脳梗塞をはじめとする脳血管障害患者において,頭蓋内血管を評価することは重
要であり,簡便に評価できる経頭蓋超音波検査の有用性は大きい。骨条件によっては十分な描
出が得られないこともあるが,超音波造影剤を併用するなどして,頭蓋内動脈の狭窄,閉塞病
変の評価ができる。また,通常TCDで行われることが多い微小栓子検:出を応用して,TCCSで
気泡を頭蓋内血管でとらえ,脳梗塞の原因診断を行えることもある。脳外科領域では,脳動脈
瘤,もやもや病の診断や治療前後の評価,また,術中術後のモニターとして,内頸動脈内膜剥
離術前後の血流評価やくも膜下出血後の脳血管攣縮の評価などにも用いられ,臨床応用の幅は
広い。脳血管障害における経頭蓋超音波検査の現時点での応用について紹介する。奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.58 No.5-6 p.155-16713450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/321Journal of Nara Medical Association, 58(5-6): 155-167http://hdl.handle.net/10564/321http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/321/1/155-167p.%e8%84%b3%e8%a1%80%e7%ae%a1%e9%9a%9c%e5%ae%b3%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e7%b5%8c%e9%a0%ad%e8%93%8b%e8%b6%85%e9%9f%b3%e6%b3%a2%e6%a4%9c%e6%9f%bb.pdf13450069AA11252383Journal of Nara Medical Association585-61551672007-12-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/3222017-05-29T06:07:14Zhdl_10564_1561食事調査の精度向上に関する疫学研究 : 3日間食事記録法と写真および面接を併用する修正法との比較EPIDEMIOLOGICAL STUDY ON IMPROVING THE ACCURACY OF A DIETARY SURVEY :
COMPARISON OF THE 3-DAY DIET RECORD METHOD AND A MODIFIED METHOD SUPPLEMENTED WITH PHOTOGRAPHY AND INTERVIEWS天野, 信子diet record methodenergy intake-adjustednutrient intakesproportion of discrepancyseasonal fluctuationTo evaluate the accuracy improvement of a dietary survey focused on
estimation of dietary intake, the author compared data from the 3-day diet record method
(3DR method) with data from a modification of the method supplemented with
photography and interviews (modified 3DR method).
A dietary survey using the 3DR method was performed on 210 first or second grade
students of a women's university during April 2001 to January 2003 using the 3DR
question/answer form at each season. As the modified 3DR method, each of the students
was also required to take photographs of her meals before and after comsumption, and
participate in an interview with a registered nutritionist.
Eighty-five completed answer forms were finally collected, and the data of 1020 days in
total were analyzed. The results were as follows.
1. Both energy and nutrient intakes were estimated as significantly higher in 18 of the
37 items by the 3DR method compared with the modified 3DR method. However,
differences between the values estimated by these two methods were within at most
4%.
2.The proportion of discrepancy between the data obtained by the two methods,
analyzed by quartiles, was highest for carbohydrates at 24.2% (weighted kappa =
0.68) and lowest for calcium at 6.5% (weighted kappa = 0.91).
3.Seasonal fluctUation in the energy intake-adjusted nutrients intakes was observed
for only 6 out of 36 items by the 3DR method, but for 10 items by the modified 3DR
method.
These results suggest that the modified 3DR method is not necessarily superior to the
simple 3DR method in a mass epidemiological study.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.58 No.5-6 p.169-17913450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/322Journal of Nara Medical Association, 58(5-6): 169-179http://hdl.handle.net/10564/322http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/322/1/169-179p.%e9%a3%9f%e4%ba%8b%e8%aa%bf%e6%9f%bb%e3%81%ae%e7%b2%be%e5%ba%a6%e5%90%91%e4%b8%8a%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8b%e7%96%ab%e5%ad%a6%e7%a0%94%e7%a9%b6.pdf13450069AA11252383Journal of Nara Medical Association585-61691792007-12-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/3232017-05-29T06:07:15Zhdl_10564_1561健康関連QOLをアウトカムとした地域高齢者のコホート研究-藤原京スタディ- : 予備調査:健常高齢者の認知機能と抑うつFEASIBILITY INVESTIGATION FOR THE FUJlWARAKYO STUDY, A COHORT STUDY FOCUSING ON HEALTH-RELATED QUALITY OF LIFE AMONG THE HEALTHY ELDERLY: DEPRESSIVE AND COGNITIVE FUNCTION森川, 将行木内, 邦明橋本, 和典長内, 清行岸本, 年史岡本, 希車谷, 典男depressive symptommild cogrritive impairmentdementiahealthy elderly peopleThis feasibility investigation for the Fujiwarakyo study, a cohort study
focusing on health-related quality of life among the healthy elderly was performed for 5
days in February, 2007. Mental status, one of the investigative components, was evaluated
by Mini-Mental State Examination (MMSE), word recall test (one of the subtests of
Alzheimer's Disease Assessment Scale-cognitive component-Japanese version: ADAS-
Jco9.), and Geriatric Depression Scale, short form (GDS15). Participants consisted of 74
males (mean age: 75.2 y.o.) and 67 females (74.3 y.o.). MMSE scores were distributed from
19 to 30 ; 20 cases (14.2%) were lower than 24 points (dementia range). Mild cognitive
impairment (MCI) was found in 9 cases (6.4%), in whom MMSE scores were more than 24
points and less than 1.5 standard deviation (SD) in the word recall test. The mean
number of correct answers in the word recall test was 6.0, and they were positively
correlated with MMSE scores (R=0.41, P<0.001). GDS15 scores were 2.4 ± 2.0 (mean ±
SD) and the healthy elderly with depressive sylnptoms (≧6 points) were 18 cases (12.8%).
Scores of MMSE and GDS15 are reported to be affected by gender or education. To
exclude these effects, the Fuji'warakyo study to be performed in future is going to
consider factors such as gender and education for evaluation dementia, MCI and
depressive symptoms.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.58 No.5-6 p.181-18713450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/323Journal of Nara Medical Association, 58(5-6): 181-187http://hdl.handle.net/10564/323http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/323/1/181-187p.%e5%81%a5%e5%ba%b7%e9%96%a2%e9%80%a3QOL%e3%82%92%e3%82%a2%e3%82%a6%e3%83%88%e3%82%ab%e3%83%a0%e3%81%a8%e3%81%97%e3%81%9f%e5%9c%b0%e5%9f%9f%e9%ab%98%e9%bd%a2%e8%80%85%e3%81%ae%e3%82%b3%e3%83%9b%e3%83%bc%e3%83%88%e7%a0%94%e7%a9%b6.pdf13450069AA11252383Journal of Nara Medical Association585-61811872007-12-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/3242017-05-29T06:06:56Zhdl_10564_1561神経疾患とメタボリックシンドローム : 通院患者における合併頻度ASSOCIATION OF NEUROLOGICAL DISEASES WITH METABOLIC SYNDROME AMONG OUT-PATIENTS上野, 聡降矢, 芳子杉江, 和馬川原, 誠形岡, 博史斉藤, こずえ桐山, 敬生木下, 聡子平野, 牧人metabolic syndromevisceral fatneurological diseasesBackground and Objective: Metabolic syndrome (MetS) is highly prevalent
in Japan; however, most previous surveys have studied only adults able to engage fully
in normal daily activities, after excluding persons with diseases or disabilities. Recently,
lifestyle-related risk factors have been strongly linked to a number of major diseases. In
particular, the incidence of atherosclerotic vascular diseases associated with MetS has
increased markedly, and this trend is projected to continue. We focused on the prevalence
of MetS among out-patients with neurological diseases.
Patients and methods: The subjects for this hospital-based study were 713 out-patients
with various neurological diseases (329 men, mean age 65.2 ± 14.5 yr, age range 40-78 yr,
and 384 women, mean age 64.6 ± 15.3 yr, age range 40-88 yr) who presented at the
Department of Neurology, Nara Medical University Hospital. A total of 120 patients had
cerebral infarction, 102 Parkinson's disease, 32 spinal spondylosis, 30 headache, 32
myositis, and the rest various other neurological diseases. MetS was diagnosed according
to the criteria proposed by The Japanese Society of Internal Medicine in 2005. The cutoff
values for waist circumference (WC) were greater than 85 cm in men and 90 cm in
women. A diagnosis of MetS additionally required two or more of the following: a serum
triglyceride level (TG) of at least 150 mg/dl and/or a high-density lipoprotein cholesterol
level (HDLC) of less than 40 mg/dl; a blood pressure (BP) of greater than 130/85; or a
fasting plasma glucose level (FPG) of greater than 110 mg/dl. Visceral fat accumulation
was measured by abdominal CT scanning (N2systern, K.K., Japan).
Results: WC positively correlated with visceral fat area as determined by CT
scanning. WC also positively correlated with TG in both sexes and FBS in women, but
negatively correlated with HDL-C in both sexes. The mean prevalence of MetS among
subjects 40 to 70 years of age was 25.1% in men and 12.6% in women. To assess the
incidence of MetS in the absence of cerebrovascular disease (CVD), we performed a
subgroup analysis of patients with and without CVD. The risk of MetS was similar in out-
patients without CVD and those with CVD. The prevalence of Pre MetS (defined as WC
plus one risk factor) plus MetS was 50% in men and 20% in women. The prevalence of
MetS in outpatients with neurological diseases was similar to that in the general
population.
Conclusion: The risk of atherosclerotic diseases in out-patients with neurological
diseases is similar to that in the general population, potentially increasing the risk of
unfavorable outcomes. The recognition and management of MetS represents an important
challenge for physicians and other healthcare professionals. Strategies aimed at reducing
risk factors for MetS are urgently required.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.58 No.5-6 p.189-19613450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/324Journal of Nara Medical Association, 58(5-6): 189-196http://hdl.handle.net/10564/324http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/324/1/189-196p.%e7%a5%9e%e7%b5%8c%e7%96%be%e6%82%a3%e3%81%a8%e3%83%a1%e3%82%bf%e3%83%9c%e3%83%aa%e3%83%83%e3%82%af%e3%82%b7%e3%83%b3%e3%83%89%e3%83%ad%e3%83%bc%e3%83%a0.pdf13450069AA11252383Journal of Nara Medical Association585-61891962007-12-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/3252017-06-11T23:20:26Zhdl_10564_1561第127回奈良医学会 : 学会記事第127回奈良医学会学会記事奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.58 No.5-6 p.197-19913450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/325Journal of Nara Medical Association, 58(5-6): 197-199http://hdl.handle.net/10564/325http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/325/1/197-199p.%e7%ac%ac127%e5%9b%9e%e5%a5%88%e8%89%af%e5%8c%bb%e5%ad%a6%e4%bc%9a_%ef%bc%9a_%e5%ad%a6%e4%bc%9a%e8%a8%98%e4%ba%8b.pdf13450069AA11252383Journal of Nara Medical Association585-61971992007-12-31jpnpublisher