2024-03-29T06:23:15Zhttp://ginmu.naramed-u.ac.jp/dspace-oai/request
oai:ginmu.naramed-u.ac.jp:10564/822017-05-29T06:06:34Zhdl_10564_1553表紙、目次、総目次、投稿規程詳細、奥付(Vol.53 No.5-6)表紙目次総目次投稿規程詳細奥付奈良医学会奈良県立医科大学OtherOthersapplication/pdfJournal of Nara Medical Association Vol.53 No.5-613450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/82Journal of Nara Medical Association, 53(5-6)http://hdl.handle.net/10564/82http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/82/1/000p.%e8%a1%a8%e7%b4%99%e3%80%81%e7%9b%ae%e6%ac%a1%e3%80%81%e7%b7%8f%e7%9b%ae%e6%ac%a1%e3%80%81%e6%8a%95%e7%a8%bf%e8%a6%8f%e7%a8%8b%e8%a9%b3%e7%b4%b0%e3%80%81%e5%a5%a5%e4%bb%98.pdf13450069AA11252383Journal of Nara Medical Association535-62002-12-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/832017-05-29T06:09:39Zhdl_10564_1553口腔癌に対する化学・放射線併用療法と臓器・機能温存への応用CHEMORADIOTHERAPY AND ITS APPLICATION TO ORGAN-FUNCTION PRESERVATION FOR ORAL CANCER桐田, 忠昭oral cancerchemoradiotherapyorgan-function preservationhead and neck cancer口腔癌は大部分が扁平上皮癌により占められ,放射線治療に対し比較的感受性が高いため,早期症例には根治治療として放射線が選択される場合も多い。しかし,多くを占める進展症例に対しては,放射線単独での効果は期待できず,また,neoadjuvant chemotherapy(NAC)を代表とされる化学療法も予後の改善までには至っていない。しかし,両者の併用によって,少量の照射線量で著明な腫瘍縮小効果が認められ,より高い局所制御が得られたり,低い線量時点での効果判定で局所制御や予後がある程度予測でき,治療法の変更が可能になるなど利点は大きい。また,手術を回避したり,より侵襲度の少ない縮小手術により口腔,顎,顔面領域の臓器・機能温存を図る治療形態も試みられてきている。本稿では,現時点での口腔進展癌に対するchemoradiotherapyの有用性と治療における位置付けを示し,将来展望についても言及した。奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.53 No.5-6 p.213-22513450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/83Journal of Nara Medical Association, 53(5-6): 213-225http://hdl.handle.net/10564/83http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/83/1/213-225p.%e5%8f%a3%e8%85%94%e7%99%8c%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%8c%96%e5%ad%a6%e3%83%bb%e6%94%be%e5%b0%84%e7%b7%9a%e4%bd%b5%e7%94%a8%e7%99%82%e6%b3%95%e3%81%a8%e8%87%93%e5%99%a8%e3%83%bb%e6%a9%9f%e8%83%bd%e6%b8%a9%e5%ad%98%e3%81%b8%e3%81%ae%e5%bf%9c%e7%94%a8%ef%bc%88%e6%a1%90%e7%94%b0%e5%bf%a0%e6%98%ad%ef%bc%89.pdf13450069AA11252383Journal of Nara Medical Association535-62132252002-12-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/842017-05-29T06:06:34Zhdl_10564_1553病理診断学 過去、現在、未来DIAGNOSTIC PATHOLOGY. PAST, PRESENT AND FUTURE市島, 國雄山田, 英二吉川, 隆幸榎本, 泰典田村, 智美井上, 和也surgical pathologydiagnostic pathologyanatomical pathologybiopsy病理学は“疾病理論の学”であり,この中には疾病の本態,原因などを探求する基礎的研究と,これをもとにして疾病の診断を行う病理診断学の二つの方向がある。日本の病理学ではこれまで前者の基礎的な研究に重点がおかれ,数多くの優れた成果が得られている。後者の病理診断学では疾病の確定診断を行うことから患者の治療,予後などに重要な情報を提供し診療上極めて重要であり,特に近年臨床医学の発展に伴いその充実が求められるようになってきている。ここでは病理診断学について過去を振り返り,現在の問題点,未来の展望などを考
察する。奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.53 No.5-6 p.227-23413450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/84Journal of Nara Medical Association, 53(5-6): 227-234http://hdl.handle.net/10564/84http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/84/1/227-234p.%e7%97%85%e7%90%86%e8%a8%ba%e6%96%ad%e5%ad%a6%ef%bd%9e%e9%81%8e%e5%8e%bb%e3%80%81%e7%8f%be%e5%9c%a8%e3%80%81%e6%9c%aa%e6%9d%a5%ef%bd%9e%ef%bc%88%e5%b8%82%e5%b3%b6%e5%9c%8b%e9%9b%84%e3%81%bb%e3%81%8b%ef%bc%89.pdf13450069AA11252383Journal of Nara Medical Association535-62272342002-12-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/852017-05-29T06:07:07Zhdl_10564_1553小児の尿路感染症の部位診断における尿中LDHアイソザイム分析の有用性URINARY LACTIC DEHYDROGENASE ISOENZYME ANALYSIS
AVAILABLE FOR LOCALIZING THE SITE OF INFECTION IN CHILDREN WITH URINARY TRACT INFECTION松永, 健司赤澤, 英樹武山, 雅博矢本, 陽子urinary LDH isoenzyme analysischildren,urinary tractinfection,urinary tract infectionpyelonephritiscystitisClinical differentiation between pyelonephritis and cystitis is often difficult to determine in infants and children. Precise localization of the site of infection is important from a therapeutic and prognostic standpoint in children with urinary tract infection (UTI). The present investigation was undertaken to determine whether or not
urinary lactic dehydrogenase (LDH) isoenzyme analysis could be available for
differentiation between upper UTI and lower UTI. Fourteen children 2 months to 15 yr
of age constituted the subjects for the study. Urinary LDH isoenzyme analyses were
performed using cellulose acetate membrane electrophoresis. On the basis of the patterns of urinary LDH isoenzymes, patients were divided into two groups. Of 14 patients, 10 (group I) showed predominant elevations of LDH1 and LDH2 (fast zone pattern) in the urine. In the remaining four (group II), urinary LDH predominantly consisted of LDH4 and LDH5 (slow zone pattern). Clinical findings revealed that body temperatures were
significantly higher in group II than in group I. Laboratory findings showed that the
serum levels of C-reactive protein (CRP) and urinary levels of β2 microglobulin were
slgnificantly higher in group II than in group I. Therefore, patients in group I were
compatible with lower UTI and patients in group II with pper UTI. This study shows the urinary LDH isoenzyme analysis to be useful for differentiation between upper UTI and lower UTI in children.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.53 No.5-6 p.235-23913450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/85Journal of Nara Medical Association, 53(5-6): 235-239http://hdl.handle.net/10564/85http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/85/1/235-239p.%e5%b0%8f%e5%85%90%e3%81%ae%e5%b0%bf%e8%b7%af%e6%84%9f%e6%9f%93%e7%97%87%e3%81%ae%e9%83%a8%e4%bd%8d%e8%a8%ba%e6%96%ad%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e5%b0%bf%e4%b8%adLDH%e3%82%a2%e3%82%a4%e3%82%bd%e3%82%b6%e3%82%a4%e3%83%a0%e5%88%86%e6%9e%90%e3%81%ae%e6%9c%89%e7%94%a8%e6%80%a7%ef%bc%88%e6%9d%be%e6%b0%b8%e5%81%a5%e5%8f%b8%e3%81%bb%e3%81%8b%ef%bc%89.pdf13450069AA11252383Journal of Nara Medical Association535-62352392002-12-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/862017-06-11T23:20:26Zhdl_10564_1553N-nitr osobis(2-oxopr opyl)amineによるハムスター膵管癌発生に対するウシおよびサメ軟骨水抽出物の影響EFFECTS OF BOVINE AND SHARK CARTILAGE WATER EXTRACTS ON PANCREATIC DUCTAL CARCINOGESIS IN HAMSTERS村田, 奈保hamsterpancreasshark cartilagechemopreventionEffects of shark cartilage water-extract (SCE) and bovine cartilage water-extract
(BCE) on pancreatic duct carcinogenesis were investigated using a rapid
production model for pancreatic duct carcinoma in hamsters, and the following results
were obtained.
1. SCE inhibited activities of MMP-2 and MMP-9 but BCE did not in vitro.
2. BCE did not have beneficial effects on chemoprevention of pancreatic carcinomas.
3. No toxic signs, including growth retardation or loss of pancreatic and liver weights, were observed in hamsters treated with BOP followed by SCE.
4. The diet containing O.4% SCE reduced significantly the numbers of adenocarcinomas
and ductallesions.
5. SCE did not affect the BrdU labeling indices of pancreatic ductal lesions.
6. SCE did not affect expression levels of proenzyme form of MMP-2 and MMP-9 and enzyme form of MMP-2 in adenocarcinomas.
These results indicate that SCE possesses inhibitory effects on development of pancreatic carcinomas and that SCE may be a candidate of chemopreventive agent for pancreatic carcinomas.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.53 No.5-6 p.241-25213450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/86Journal of Nara Medical Association, 53(5-6): 241-252http://hdl.handle.net/10564/86http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/86/1/241-252p.N-nitr_osobis%282-oxopr_opyl%29amine%e3%81%ab%e3%82%88%e3%82%8b%e3%83%8f%e3%83%a0%e3%82%b9%e3%82%bf%e3%83%bc%e8%86%b5%e7%ae%a1%e7%99%8c%e7%99%ba%e7%94%9f%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e3%82%a6%e3%82%b7%e3%81%8a%e3%82%88%e3%81%b3%e3%82%b5%e3%83%a1%e8%bb%9f%e9%aa%a8%e6%b0%b4%e6%8a%bd%e5%87%ba%e7%89%a9%e3%81%ae%e5%bd%b1%e9%9f%bf%ef%bc%88%e6%9d%91%e7%94%b0%e5%a5%88%e4%bf%9d%ef%bc%89.pdf13450069AA11252383Journal of Nara Medical Association535-62412522002-12-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/872017-06-11T23:20:26Zhdl_10564_1553動・静脈血栓形成過程に関する基礎的研究 走査および透過電子顕微鏡による観察EXPERIMENTAL STUDY OF ARTERIAL AND VENOUS
THROMBUS FORMATION BY SCANNING AND TRANSMISSION
ELECTRON MICROSCOPE金, 雄一arterial and venous thrombosisendothelial cellphotochemical dyeelectron microscoperatThe process of thrombus formation at arterial and venous endothelial surfaces was examined by scanning electron microscope (SEM) and transmission electron
microscope (TEM) in a photochemical occlusion model.The rats were divided into the following 4 groups after the injection of rose bengal:1) control group (n=5)without illumination; 2) group A (n=10) irradiated for 1 min; 3) group B (n=10) for 5 min; 4) group C (n=14) for lO min at cervical artery and vein. As a result, SEM findings showed adhesion of blood platelets and endothelial damage in neither artery nor vein in control and A groups. Plasma membrane damage of endothelial cells (i.e. plasmalemmal pits, the crater-like structure associated with tear between endothelial cells, and decreased number of microvilli) was recognized in arterial
wall, but these changes were not observed in vein in group B. Adhesion of blood
platelets in addition to endothelial cell membrane obstacle in artery was remarkable by SEM examination and tear between arterial endothelial cells was found by TEM
examination in group C. The degree of adhesion of platelets was clearly remarkable in artery compared with vein.
In conclusion, endothelial cell membrane injury, tear between endothelial cells and
endothelial detachment occur before adhesion of blood platelets and thrombus formation in a blood vessel occlusion model by photochemical reaction. These changes occur significantly earlier in artery than in vein.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.53 No.5-6 p.253-26113450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/87Journal of Nara Medical Association, 53(5-6): 253-261http://hdl.handle.net/10564/87http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/87/1/253-261p.%e5%8b%95%e3%83%bb%e9%9d%99%e8%84%88%e8%a1%80%e6%a0%93%e5%bd%a2%e6%88%90%e9%81%8e%e7%a8%8b%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8b%e5%9f%ba%e7%a4%8e%e7%9a%84%e7%a0%94%e7%a9%b6_-_%e8%b5%b0%e6%9f%bb%e3%81%8a%e3%82%88%e3%81%b3%e9%80%8f%e9%81%8e%e9%9b%bb%e5%ad%90%e9%a1%95%e5%be%ae%e9%8f%a1%e3%81%ab%e3%82%88%e3%82%8b%e8%a6%b3%e5%af%9f_-_%ef%bc%88%e9%87%91%e9%9b%84%e4%b8%80%ef%bc%89.pdf13450069AA11252383Journal of Nara Medical Association535-62532612002-12-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/882017-05-29T06:06:35Zhdl_10564_1553出生当日に発症した発作性上室性頻拍症にATPが有効であった低出生体重児の1例SUCCESSFUL TREATMENT OF PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA IN A LOW-BIRTH-WEIGHT NEWBORN BY INJECTION OF ADENOSINE-5'-TRIPHOSPHATE古市, 康子吉田, 裕慈川口, 千晴桑原, 勲箕輪, 秀樹江國, 豊吉岡, 章高橋, 幸博松村, 正彦ATPparoxysmal supraventricular tachycardialow-birth-weight newbornWe report a case in which paroxysmal supraventricular tachycardia (PSVT) in a low-birth-weight newborn, due to atrioventricular nodal re-entry, was
successfully treated by intravenous bolus injection of adenosine-5'-triphosphate (ATP). The newborn was a male, born after 36 weeks and 1 day of gestation, weighing 2,204g. One hour after birth, he exhibited tachycardia, at 250 to 270 beats/min. A chest radiogragh revealed cardiomegaly, with a cardiothoracic ratio of 71%. Injection of ATP at a dose of O.3mg/kg resulted in complete cessation of PSVT, with temporary suppression of the sinus node and resumption of normal sinus rhythm within 10 seconds after injection.
No serious side effects of ATP injection occurred. Oral digoxin treatment was
administered for 10 months after ATP injection, to prevent recurrence of tachycardia. The patient is now 3 years and 2 months old, and there has been no recurrence of tachycardia.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.53 No.5-6 p.263-26713450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/88Journal of Nara Medical Association, 53(5-6): 263-267http://hdl.handle.net/10564/88http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/88/1/263-267p.%e5%87%ba%e7%94%9f%e5%bd%93%e6%97%a5%e3%81%ab%e7%99%ba%e7%97%87%e3%81%97%e3%81%9f%e7%99%ba%e4%bd%9c%e6%80%a7%e4%b8%8a%e5%ae%a4%e6%80%a7%e9%a0%bb%e6%8b%8d%e7%97%87%e3%81%abATP%e3%81%8c%e6%9c%89%e5%8a%b9%e3%81%a7%e3%81%82%e3%81%a3%e3%81%9f%e4%bd%8e%e5%87%ba%e7%94%9f%e4%bd%93%e9%87%8d%e5%85%90%e3%81%ae1%e4%be%8b%ef%bc%88%e5%8f%a4%e5%b8%82%e5%ba%b7%e5%ad%90%e3%81%bb%e3%81%8b%ef%bc%89.pdf13450069AA11252383Journal of Nara Medical Association535-62632672002-12-31jpnpublisher