2024-03-29T12:44:11Zhttp://ginmu.naramed-u.ac.jp/dspace-oai/request
oai:ginmu.naramed-u.ac.jp:10564/5102017-06-11T23:20:26Zhdl_10564_1531表紙、目次、投稿規定、奥付(Vol.50 No.3)表紙目次投稿規定奥付奈良医学会OtherOthersapplication/pdfJournal of Nara Medical Association Vol.50 No.313450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/510Journal of Nara Medical Association, 50(3)http://hdl.handle.net/10564/510http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/510/1/000p.%e8%a1%a8%e7%b4%99%e3%80%81%e7%9b%ae%e6%ac%a1%e3%80%81%e6%8a%95%e7%a8%bf%e8%a6%8f%e5%ae%9a%e3%80%81%e5%a5%a5%e4%bb%98%28Vol.50_No.3%29.pdf13450069AA11252383Journal of Nara Medical Association5031999-06-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/5112017-05-29T06:06:54Zhdl_10564_1531水晶体再充填物質としてのポリビニルアルコールの生体適合性BIOCOMPATIBILITY OF POLYVINYLALCOHOL AS LENS REFILLING坂ノ下, 和弘名和, 良晃増田, 紀子塚本, 光雄原, 嘉昭西信, 元嗣lens epithelial cellspolyvinyl alcohollens refillingposterior capsular opacificationWe have developed an intraocular lens that restores ocular accomodation.
In designing an intraocular lens with the capability of accomodation, it is essential that the
substance refilling the lens capsule does not induce posterior capsular opacification (PCO).
We compared the effect of polyvinyl alcohol (PVA), polyvinyl pryrrolidone (PVP) and
silicone on the cultured bovine lens epithelial cells (LECs). We evaluated the cell prolifera-
tion, the growth potential, the contractile activity and the morphological change of LECs.
Growth potential was measured by BrdU immunohistochemical staining, contractile activ-
ity was measured by α-smooth muscle actin (α-SMA) expression and morphological
change of LECs was observed via phase-contrast microscopy. The presence of PVP and
silicone in the culture medium did not inhibit proliferation of LECs, and α-SMA-positive
cells appeared in the medium containing silicone. The results suggest that silicone may
induce PCO. Growth potential, detected by immunohistochemistry of BrdU, showed no
difference between PVA, PVP, and silicone. The pres"ence of PVA in the cultured medium
inhibited proliferation of LECs, did not produce α-SMA-positive cells, and changed the
morphology of LECs to be spherical. The effect was dose-dependent. PVA also suppressed
intercellular adhesion. PVA promises to be a candidate as refilling substance of the lens
capsule, although further investigation with regard to its biocompatibility will be reguired.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.50 No.3 p.165-17313450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/511Journal of Nara Medical Association, 50(3): 165-173http://hdl.handle.net/10564/511http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/511/1/165-173p.%e6%b0%b4%e6%99%b6%e4%bd%93%e5%86%8d%e5%85%85%e5%a1%ab%e7%89%a9%e8%b3%aa%e3%81%a8%e3%81%97%e3%81%a6%e3%81%ae%e3%83%9d%e3%83%aa%e3%83%93%e3%83%8b%e3%83%ab%e3%82%a2%e3%83%ab%e3%82%b3%e3%83%bc%e3%83%ab%e3%81%ae%e7%94%9f%e4%bd%93%e9%81%a9%e5%90%88%e6%80%a7.pdf13450069AA11252383Journal of Nara Medical Association5031651731999-06-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/5122017-05-29T06:06:52Zhdl_10564_1531透析膜生体適合性評価におけるHPLCによる血清ネオプテリン測定の有用性 : ビタミンE固相化改質セルロース膜における基礎的・臨床的評価SERUM NEOPTERIN AS THE MARKER FOR BIOCOMPATIBILITY IN HEMODIALYSIS : EXPERIMENTAL AND CLINICAL EVALUATION OF VITAMIN E COATED CELLULOSE DIALYZER BY SERUM NEOPTERIN中辻, 史好米田, 龍生影林, 頼明大園, 誠一郎平尾, 佳彦吉田, 克法NeopterinHemodialysisVitamin-E coated dialyzerBiocompatibilityExposure of blood to hemodialysis membranes results in numerous phenom-
ena or complications in hemodialysis (HD) patients, and these complications influence the
quality of life (QOL) in HD patients. Vitamin E coated cellulose dialyzer (E-membrane)
is developed to act as scavenger for reactive oxgen species which couse complications in
HD patients.
Neopterin (NEOP) is the metabolites derived from guanosine triphosphate. Recently it
was shown that production and release of NEOP is induced in monocyte and macrophages
by cytokines such as interferon gamma (IFN-γ). And it is surmised to be as a reactive
marker of biocompatibility of dialysis membrane in hemodialyzed patients.
In this study, we evaluated the usefulness of serum NEOP as a marker for
biocompatibility of dialyzer by the use of E-membrane and control membrane in experimen-
tal and clinical study. In experimental study in using dogs, exracorporal circulation with
E-membrane and control membrane, the serial levels of serum NEOP in dogs using E-
membrane were lower than those of control membrane about the ratio of serum NEOP. In
clinical study, during extracorporal ultrafiltration methods (ECUM), the levels of serum
NEOP in patients using E-membranes were lower than those in patients using control
membranes. In long time evaluation of biocompatibility of there two membranes, the ratio
of increasing of serum NEOP using control membranes was higher than that using E-
membranes.
By evaluation of serum NEOP for biocompatibility of membrane in dialysis, our observa-
tion showed that serum NEOP is useful as a marker of biocompatibility in hemodialysis
membrane.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.50 No.3 p.174-18213450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/512Journal of Nara Medical Association, 50(3): 174-182http://hdl.handle.net/10564/512http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/512/1/174-182p.%e9%80%8f%e6%9e%90%e8%86%9c%e7%94%9f%e4%bd%93%e9%81%a9%e5%90%88%e6%80%a7%e8%a9%95%e4%be%a1%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bHPLC%e3%81%ab%e3%82%88%e3%82%8b%e8%a1%80%e6%b8%85%e3%83%8d%e3%82%aa%e3%83%97%e3%83%86%e3%83%aa%e3%83%b3%e6%b8%ac%e5%ae%9a%e3%81%ae%e6%9c%89%e7%94%a8%e6%80%a7.pdf13450069AA11252383Journal of Nara Medical Association5031741821999-06-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/5132017-05-29T06:06:54Zhdl_10564_1531某艦船修理事業場における石綿曝露労働者の歴史的コホート研究A HISTORICAL COHORT STUDY OF WORKERS EXPOSED TO ASBESTOS IN A REFITTING SHIPYARD水谷, 理香asbestoshistorical cohort studylung cancerrespiratory symptomsship repair workersTo investigate the risks of developing asbestos-related diseases, we con-
ducted a historical cohort study on 249 ship repair workers (90 laggers and 159 boiler
repairers) in a single refitting shipyard in Yokosuka city, Japan. We successfully identified
the vital status of 87 (96.7%) laggers and 150 (94.3%) boiler repairers, and, of these, 49
(56.3%) and 65 (43.3%) died, respectively, during the follow-up period from 1947 till the
end of 1996. Our in-person interviews with some of the subjects clarified that asbestos
exposure was considered to be substantially high in the 1950-60s, decreased thereafter
gradually but remained till the end of 1979 in the shipyard. The laggers, who had handled
asbestos materials directly, showed a significantly elevated SMR (Standardized Mortality
Ratio) of 2.8 [95 % C.I. (Confidence Interval) : 1.1-6.5] for lung cancer. The magnitude
of the risk developing the cancer was greater after considering a 20-year latency (SMR=
3.4). Pancreatic cancer also yielded a greater SMR than unity (5.2, 90% C.I. : 1.4-16.9)
in the 20-year latency group. Four laggers died from asbestosis. The boiler repairers, who
had many chances for secondary exposure to asbestos and a few for direct exposure,
showed no elevation of the SMR of lung cancer in either the overall group or the group after
a 20-year latency. One boiler repairer died from mesothelioma and four from asbestosis.
We were able to interview 71 among 85 living retired workers. Forty-three (60.6%) of
them had been diagnosed to have asbestosis by physicians. The prevalence of the subjects
having asbestosis and working for 180 months and more was significantly higher than that
among those working for a shorter period after adjusting the different distributions of ages
and smoking habits. These results suggested that asbestos exposure in the refitting
shipyard causally related to some types of malignant neoplasms among the deceased and to
respiratory symptoms among the living retired workers.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.50 No.3 p.183-19513450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/513Journal of Nara Medical Association, 50(3): 183-195http://hdl.handle.net/10564/513http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/513/1/183-195p.%e6%9f%90%e8%89%a6%e8%88%b9%e4%bf%ae%e7%90%86%e4%ba%8b%e6%a5%ad%e5%a0%b4%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e7%9f%b3%e7%b6%bf%e6%9b%9d%e9%9c%b2%e5%8a%b4%e5%83%8d%e8%80%85.pdf13450069AA11252383Journal of Nara Medical Association5031831951999-06-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/5142017-05-29T06:06:52Zhdl_10564_1531手掌多汗症に対する胸腔鏡下交感神経遮断術の検討CLINICAL EVALUATION OF ENDOSCOPIC TRANSTHORACIC SYMPATHECTOMY FOR PALMER HYPERHIDROSIS呉原, 弘吉山上, 裕章橋爪, 圭司中橋, 一喜山口, 綾子岸, 勝佳古家, 仁endoscopic transthoracic sympathectomypalmer hyperhidrosiscompensatory sweatingTo assess the effects of endoscopic transthoracic sympathectomy (ETS)
for palmer hyperhidrosis, we performed the retrospective study included chart reviews and
outpatient assessments. Twenty-two patients (19 females and 3 males, mean age 26.2
years) with palmer hyperhidrosis underwent bilateral T2-T3 ETS from October 1997 to
December 1998 in our hospital. The symptomatic improvement rate of ETS was 100%. All
patients suffered from compensatory sweating, which was the main cause of patients'
dissatisfaction postoperatively. Five patients experienced other complications, including
pneumothorax (one case), shoulder pain (two cases) and intercostal neuralgia (two cases).
There was no severe complication in our series. We conclude that EST is an effective and
safety treatment for palmer hyperhidrosis. However, all patients need to be warned of the
common complications, particularly compensatory sweating, before surgery.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.50 No.3 p.196-20013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/514Journal of Nara Medical Association, 50(3): 196-200http://hdl.handle.net/10564/514http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/514/1/196-200p.%e6%89%8b%e6%8e%8c%e5%a4%9a%e6%b1%97%e7%97%87%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e8%83%b8%e8%85%94%e9%8f%a1%e4%b8%8b%e4%ba%a4%e6%84%9f%e7%a5%9e%e7%b5%8c%e9%81%ae%e6%96%ad%e8%a1%93%e3%81%ae%e6%a4%9c%e8%a8%8e.pdf13450069AA11252383Journal of Nara Medical Association5031962001999-06-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/5152017-06-11T23:20:26Zhdl_10564_1531口腔扁平上皮癌におけるMatrix metalloproteinaseとTissue inhibitor of metalloproteinaseの発現と局在についての検討EXPRESSION AND LOCALIZATION OF MATRIX METALLOPROTEINASES AND TISSUE INHIBITOR OF METALLOPROTEINASES IN ORAL SQUAMOUS CELL CARCINOMA松岡, 弘樹美島, 健二山田, 英二市島, 國雄高山, 賢一山本, 一彦杉村, 正仁Matrix metalloproteinase (MMP)Tissue inhibitor of metalloproteinase (TIMP)Squamous cell carcinomaImmunohistochemical stainings of matrix metalloproteinase (MMP)-2, 9
and tissue inhibitor of metalloproteinase (TIMP)-1, 2, 3 with specific antibodies in paraffin
sections of 14 human oral squamous cell carcinomas and 8 normal tissues were perfomed by
labeled streptavidinbiotin method. The expression and localization of mRNA of TIMP-1,
2, 3 were studied by in situ hybridization with digoxigenin (DIG) RNA probe in the same
specimens. Positive immunostaining for MMP-2, 9 and TIMP-1 were detected in stromal
cells of carcinoma, whereas positive staining for TIMP-3 was detected in both stromal cells
and cytoplasms of carcinoma cells. Diffuse expression of MMP-2, 9 was observed in
carcinomas with advanced stages. They were not detected in normal tissues. Expressions
of TIMP-3 mRNA were observed in 11 out of 14 carcinomas. They were seen in stromal
cells and in cytoplasms of cardinoma cells (7/4 in only stromal cells and 4/14 in both
stromal cells and carcinoma cells). Carcinomas expressing TIMP-3 mRNA tended to be
smaller in size than those which were non-expressing. TIMP-3 mRNA was not detected in
normal tissues. Our results suggest that MMP-2, 9 are important for the development of
oral squamous cell carcinoma and TIMP-3 is an important inhibitor of it.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.50 No.3 p.201-20713450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/515Journal of Nara Medical Association, 50(3): 201-207http://hdl.handle.net/10564/515http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/515/1/201-207p.%e5%8f%a3%e8%85%94%e6%89%81%e5%b9%b3%e4%b8%8a%e7%9a%ae%e7%99%8c%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bMatrix_metalloproteinase.pdf13450069AA11252383Journal of Nara Medical Association5032012071999-06-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/5162017-06-11T23:20:26Zhdl_10564_1531ANGIOTENSIN Ⅱ TYPE Ⅰ RECEPTOR AND ANGIOTENSINOGEN GENE POLYMORPHISMS IN PATIENTS WITH CORONARY ARTERY DISEASETomoda, YoshioUemura, ShiroHamano, KazumasaAkai, YasuhiroIwano, MasayukiHashimoto, ToshioDohi, Kazuhiroangiotensin Ⅱ type Ⅰ receptorangiotensinogengene polymorphismcoronary artery diseaseTo analyze the participation of genetic factors in the onset and process of
coronary arteriosclerosis, we investigated the distribution of both angiotensin Ⅱ type Ⅰ
receptor (AT1R) and angiotensinogen (ATN) gene polymorphisms, and the relationship
between genotype and clinical features in patients with coronary artery disease (CAD). We
studied 139 CAD patients (CAD group : 93 males, 46 females, mean age of 62 y/o) consisting
of 118 with myocardial infarction and 21 with angina pectoris. We selected 133 healthy
volunteers without overt cardiac heart disease as control subjects. Al166C polymorphism
of the AT1R gene (A → C transversion at position 1166 of AT1R gene) and T174M polymorphism of ATN gene (T → M transversion at position 174 of ATN gene) were determined by
PCR of genomic DNA extracted from peripheral leukocytes and digestion with restriction
enzyme. Patients were classified into one of three genotypes, AA homozygote, AC
heterozygote and CC homozygote for AT1R, TT, TM and MM for ATN. The distribution
of AT1R and ATN genotype did not differ between CAD patients and control subjects.
Neither AT1R nor ATN genotype was correlated with the severity of coronary arteriosclerosis. In AT1R gene polymorphism, AC and CC genotype were significantly more frequent
in patients with than in those without restenosis. In ATN gene polymorphism, TT genotype
was also significantly more frequent in patients with than in those without restenosis. In
conclusion, both ATIR and ATN gene polymorphism may participate in the process of
restenosis after coronary angioplasty.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.50 No.3 p.208-21413450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/516Journal of Nara Medical Association, 50(3): 208-214http://hdl.handle.net/10564/516http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/516/1/208-214p.ANGIOTENSIN_%e2%85%a1_TYPE_%e2%85%a0_RECEPTOR_AND_ANGIOTENSINOGEN.pdf13450069AA11252383Journal of Nara Medical Association5032082141999-06-30engpublisher
oai:ginmu.naramed-u.ac.jp:10564/5172017-05-29T06:06:54Zhdl_10564_1531C型慢性肝炎に対するインターフェロン療法の治療成績(Ⅱ)A TRIAL OF INTERFERON TREATMENT FOR CHRONIC HEPATITIS C上田, 重彦城井, 啓吉川, 佳嗣安, 辰一鎌田, 修松下, 和広山根, 佳子池中, 康英伯者, 徳之簗瀬, 公嗣山尾, 純一菊池, 英亮栗山, 茂樹福居, 健一植村, 正人松村, 雅彦高谷, 章福井, 博吉川, 正英中野, 博interferonchronic hepatitis CInterferon (IFN) is the only drug that has been approved by the FDA for
therapy of chronic hepatitis C. We conducted a trial of IFN therapy for chronic hepatitis
C. Eighty-eight patients with chronic hepatitis C were enrolled for the IFN trial. Either
9 million units (MU) of recombinant IFN α-2a (rIFN) or 6 MU of Iymphoblastoid IFNα
(nIFN) was administered daily for 4 weeks and then three times a week for 22 weeks. IFN
therapy was interrupted in 11 patients due to adverse reaction to IFN. In addition, a course
of observation including blood sampling was not enough to analyze IFN response in 21
subjects. Therefore, IFN response was evaluated in the remaining 56 patients. Complete
response (CR), defined as sustained normalization of serum transaminase values for more
than 6 months after the treatment, was obtained in 18 (32.1%). The CR rate in the present
IFN trial did not differ significantly from that (28.4%) in our previous IFN trial which
either 9 MU of rIFN or 3 MU of nIFN was administered daily for 2 weeks and then three
times a week for 22 weeks, suggesting that an increase in the total dose of interferon failed
to yield further benefit in patients with chronic hepatitis C.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.50 No.3 p.215-21913450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/517Journal of Nara Medical Association, 50(3): 215-219http://hdl.handle.net/10564/517http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/517/1/215-219p.C%e5%9e%8b%e6%85%a2%e6%80%a7%e8%82%9d%e7%82%8e%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e3%82%a4%e3%83%b3%e3%82%bf%e3%83%bc%e3%83%95%e3%82%a7%e3%83%ad%e3%83%b3%e7%99%82%e6%b3%95%e3%81%ae%e6%b2%bb%e7%99%82%e6%88%90%e7%b8%be%28%e2%85%a1%29.pdf13450069AA11252383Journal of Nara Medical Association5032152191999-06-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/5182017-05-29T06:06:52Zhdl_10564_1531屈折矯正手術後における角膜形状が眼圧計測におよぼす影響EFFECT OF CORNEAL CONFIGURATION CHANGE ON MEASUREMENT OF INTRAOCULAR PRESSURE IN LASER KERATOREFRACTIVE SURGERY小南, 雅也魚里, 博西信, 元嗣keratorefractive surgerypostoperative IOP measurementcentral corneal thicknesscentral corneal curvaturecorneal hydrationCorneal configuration change due to recent keratorefractive surgery such
as photorefractive keratectomy (PRK), photherapeutic keratectomy (PTK), and laser in-
situ keratomileusis (LASIK) reduce the corneal rigidity, and will result in significant
underestimation of postoperative intraocular pressure (IOP) measurement. So we have
analyzed the relation between corneal cofiguration change and postoperative measurement
of IOP in keratorefractive surgery (PRK PTK, and LASIK).
Actual IOP was controlled using a manometer inserted into the anterior chamber of
enucleated pig eyes. Clinical IOP was measured with electronic applanation tonometer
(Tono-Pen XL, Menter) at several heights of manometer, central corneal thickness (CCT)
was measured with ultrasonic pachymeter (SP-2000, Tome.) before and after IOP measure-
ment, and anterior corneal curvature with Orbscan (Orbtech). Each measured IOP was
analyzed statistically with linear regression and paired t-test.
Measured IOP of the group of normal eyeball with various CCT was increased in every
experimentation as CCT increased. And measured IOP of automated lamellar keratoplasty
(ALK) performed group was significantly reduced as CCT reduced. Linear correlation was
established between set up IOP and measured IOP, with correlation coefficients close to
unity. Correlation between CCT and the measured IOP, CCT and the difference of the
measured IOP to each sample was statistically highly significant (P<0.001). Measured
anterior corneal curvature at 3 mm diameter of central cornea of the ALK performed group
was decreased as IOP increased.
Results of our investigation show that CCT has a larger effect on the measurement of IOP
than central corneal curvature and corneal hydration. We should take into consideration
the corneal configuration change for proper assessment of postoperative IOP measurement
in recent keratorefractive surgery.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.50 No.3 p.220-23213450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/518Journal of Nara Medical Association, 50(3): 220-232http://hdl.handle.net/10564/518http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/518/1/220-232p.%e5%b1%88%e6%8a%98%e7%9f%af%e6%ad%a3%e6%89%8b%e8%a1%93%e5%be%8c%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e8%a7%92%e8%86%9c%e5%bd%a2%e7%8a%b6%e3%81%8c%e7%9c%bc%e5%9c%a7%e8%a8%88%e6%b8%ac%e3%81%ab%e3%81%8a%e3%82%88%e3%81%bc%e3%81%99%e5%bd%b1%e9%9f%bf.pdf13450069AA11252383Journal of Nara Medical Association5032202321999-06-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/5192017-05-29T06:06:54Zhdl_10564_1531人工硝子体の屈折率,波長分散の術後視機能におよぼす影響THE INFLUENCE OF REFRACTIVE INDEX AND CHROMATIC DISPERSION OF THE ARTIFICIAL VITREOUS ON POSTOPERATIVE VISUAL FUNCTION志水, 敏夫vitreoussilicone oilperfluorodecalinrefractive indexchromatic aberrationIn order to make ideal artificial vitreous, it is important to have knowledge
of the opical properties of actual vitreous and vitreous replacement substance. The
measurement of the refractive index, chromatic dispersion and its thermal alteration of the
pig vitreous, silicone oil, and perfluorodecalin were made by using Abbe refrectometer. The
mean refractive index of pig vitreous was 1.3351, silicone oil 1.4053, and perfluorodecalin
1.3152 at 20℃ using wavelength of 589nm. The longer the measured wavelength the
smaller the refractive index. The refractive index tends to be small as the temperature of
measurement rises. The difference of the refractive index between 42℃ to 20℃ was very
small (The pig vitreous 0.003, silicone oil 0.009, perfluorodecalin 0.009) so that variation
of refractive index according to the thermal alteration of measurement was demonstrated
to be very small. Postoperative refraction was calculated by ray tracing method based on
Gullstrand's schematic eye. When the vitreous cavity of a phakic eye is filled with silicone
oil, 8D hyperopic shift was predicted and with perfluorodecalin 2.5D myopic shift was
predicted. Chromatic dispersion of pig eye was 0.8D, with silicone oil, 0.88D, with
perfluorodecalin 0.53D so that the chromatic aberration may unaffected by these mate-
rials, and variation of chromatic aberration according to the thermal alteration was
demonstrated to be very small.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.50 No.3 p.233-24013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/519Journal of Nara Medical Association, 50(3): 233-240http://hdl.handle.net/10564/519http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/519/1/233-240p.%e4%ba%ba%e5%b7%a5%e7%a1%9d%e5%ad%90%e4%bd%93%e3%81%ae%e5%b1%88%e6%8a%98%e7%8e%87%2c%e6%b3%a2%e9%95%b7%e5%88%86%e6%95%a3%e3%81%ae%e8%a1%93%e5%be%8c%e8%a6%96%e6%a9%9f%e8%83%bd%e3%81%ab%e3%81%8a%e3%82%88%e3%81%bc%e3%81%99%e5%bd%b1%e9%9f%bf.pdf13450069AA11252383Journal of Nara Medical Association5032332401999-06-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/5202017-05-29T06:06:52Zhdl_10564_1531角膜の屈折率分布と波長分散に関する研究DISTRIBUTION OF REFRACTIVE INDEX AND CHROMATIC DISPERSION OF THE CORNEA渡邉, 千博distribution of refractive indexAbbe numberpig cornearefractive surgeryMany refractive surgeries of the cornea (radial keratotomy RK, photore-
fractive keratectomy PRK, laser in situ keratomileusis LASIK) are done routinely in an
increasing number of patients in many countries. However, few analyses of the cornea
related to the corneal configuration change and refractive index distribution, which affect
the postoperative visual outcomes, have been reported. We have analyzed the refractive
index and chromatic dispersion of the cornea as a function of the temperature of pig eyes
in vitro. Refractive index of various depth of the cornea was measured with a multi-
wavelength Abbe refractometer at various temperatures. Experimental results show that
refractive index and Abbe number are different at the corneal position (epithelium, stroma,
endothelium). As the corneal temperature changes, the refractive index and Abbe number
also changed significantly. It is concluded that the refractive index is depending on the
axial position and the temperature. We need a further consideration of the optical
properties such as refractive index and chromatic dispersion of the cornea for obtaining
good visual outcomes after various kinds of recent refractive surgeries.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.50 No.3 p.241-25113450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/520Journal of Nara Medical Association, 50(3): 241-251http://hdl.handle.net/10564/520http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/520/1/241-251p.%e8%a7%92%e8%86%9c%e3%81%ae%e5%b1%88%e6%8a%98%e7%8e%87%e5%88%86%e5%b8%83%e3%81%a8%e6%b3%a2%e9%95%b7%e5%88%86%e6%95%a3%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8b%e7%a0%94%e7%a9%b6.pdf13450069AA11252383Journal of Nara Medical Association5032412511999-06-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/5212017-06-11T23:20:26Zhdl_10564_1531SCHWANNOMA OF THE MAXILLA : REPORT OF A CASEMatsuda, HirofumiKirita, TadaakiKawakami, TetsujiEndo, TakehiroKonishi, NoboruHiasa, YosioSugimura, Masahitoschwannomamaxillaintraosseous tumorThe patient, a 14-year-old female, underwent oral and maxillofacial sur-
gery for a swelling in her left anterior maxilla. Radiographs showed an ill-defined
radiolucency involving the alveolar bone between the roots of the left upper lateral central
incisor and second premolar. CT scans demonstrated a solid mass enclosing cystic lesions,
diagnosed as schwannoma with both Antoni type A and B patterns in examination biopsy
specimens. Immunohistochemically, S-100 proteins were strongly positive in most tumor
cells. Electron microscopic study showed the cells to be surrounded by a basal lamina with
many cytoplasmic processes and Luse body consisting of long-spacing collagen.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.50 No.3 p.252-25513450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/521Journal of Nara Medical Association, 50(3): 252-255http://hdl.handle.net/10564/521http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/521/1/252-255p.SCHWANNOMA_OF_THE_MAXILLA%e3%80%80%ef%bc%9a%e3%80%80REPORT_OF_A_CASE.pdf13450069AA11252383Journal of Nara Medical Association5032522551999-06-30engpublisher
oai:ginmu.naramed-u.ac.jp:10564/5222017-05-29T06:06:52Zhdl_10564_1531喀血で発症し経気管支肺生検で診断した過誤腫性肺脈管筋腫症の1例A CASE OF LYMPHANGIOMYOMATOSIS WITH HEMOPTYSIS DIAGNOSED BY TRANSBRONCHIAL BIOPSY岡田, 徹濱田, 薫玉置, 伸二徳山, 猛前田, 光一長, 澄人米田, 尚弘澤木, 政好成田, 亘啓中江, 大lymphangio (leio) myomatosisdiffuse pulmonary hemorrhagediagnotic methodssmooth muscleA 26-year-old female was admitted to Nara Medical University Hospital
because of hemoptysis without dyspnea. The chest x-ray revealed diffuse linear and small
nodular shadows and the chest CT scan revealed homogeneously distributed thin wall cysts.
Transbronchial lung biopsy (TBLB) specimens demonstrated nodular proliferation of
smooth muscle cells with proliferated lymph vessels and a lot of hemosiderin laden
macrophages in alveolar spaces. Out of 69 case reports with lymphangiomyomatosis in
Japan, 7 cases (10%) had hemoptysis at onset of clinical symptoms and 15 cases (22%)
were finally diagnosed by TBLB as this case.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.50 No.3 p.256-26213450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/522Journal of Nara Medical Association, 50(3): 256-262http://hdl.handle.net/10564/522http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/522/1/256-262p.%e5%96%80%e8%a1%80%e3%81%a7%e7%99%ba%e7%97%87%e3%81%97%e7%b5%8c%e6%b0%97%e7%ae%a1%e6%94%af%e8%82%ba%e7%94%9f%e6%a4%9c%e3%81%a7%e8%a8%ba%e6%96%ad%e3%81%97%e3%81%9f%e9%81%8e%e8%aa%a4%e8%85%ab%e6%80%a7%e8%82%ba%e8%84%88%e7%ae%a1%e7%ad%8b%e8%85%ab%e7%97%87%e3%81%ae1%e4%be%8b.pdf13450069AA11252383Journal of Nara Medical Association5032562621999-06-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/5232017-05-29T06:06:54Zhdl_10564_1531冠動脈バイパス術後,急速に透析療法に移行した末期腎不全の1例A CASE OF RENAL INSUFFICIENCY PROGRESSING TO END-STAGE RENAL DISEASE REQUIRING DIALYSIS AFTER CORONARY ANGIOGRAPHY AND MINIMALLY INVASIVE DIRECT CORONARY ARTERY BYPASS GRAFTING原田, 幸児川野, 貴弘山野, 繁金内, 雅夫土肥, 和紘CAG (coronary angiography)CABG (coronary artery bypass grafting)MIDCAB (minimally invasive direct coronary artery bypass grafting)contrast mediumatheroembolic renal diseaseThe patient was a 68-year-old woman with a 28-year history of hyperten-
sion. She complained of frequent episodes of exertional chest pain in about January 1981,
and was admitted to a local hospital for investigation of her chest pain. She was diagnosed
as having angina pectoris (three-vessel disease) and underwent coronary artery bypass
grafting (CABG), with double aorto-coronary bypass (saphenous vein graft to the left
anteior descending artery and saphenous vein graft to the posterior descending artery) in
May 1981. She subsequently complained of precordial oppression again and was treated
with isosorbide dinitrate. Her symptoms was worsened in January 1997. Coronary
angiography (CAG) was done in May 1997, and administered contrast medium (Iopamidol
2.72 ml/kg). Before CAG, the serum creatinine was 1.2mg/dl and after CAG it was 3.6
mg/dl. She underwent minimally invasive direct coronary artery bypass grafting (MID-
CAB) on June 23, 1997. After MIDCAB, she complained of severe abdominal pain,
appearance of severe hypertension, and her renal function worsened (serum creatinine : 7.0
mg/dl) and hemodialysis was started. When renal function worsens after CAG, in associa-
tion with the effect of contrast medium and the onset of atheroembolic renal disease,
atheroembolism can occur after CABG. In conclusion, a case of renal insufficiency
progressing to end-stage renal disease that required dialysis after CAG and MIDCAB is
reported.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.50 No.3 p.263-26613450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/523Journal of Nara Medical Association, 50(3): 263-266http://hdl.handle.net/10564/523http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/523/1/263-266p.%e5%86%a0%e5%8b%95%e8%84%88%e3%83%90%e3%82%a4%e3%83%91%e3%82%b9%e8%a1%93%e5%be%8c%2c%e6%80%a5%e9%80%9f%e3%81%ab%e9%80%8f%e6%9e%90%e7%99%82%e6%b3%95%e3%81%ab%e7%a7%bb%e8%a1%8c%e3%81%97%e3%81%9f%e6%9c%ab%e6%9c%9f%e8%85%8e%e4%b8%8d%e5%85%a8%e3%81%ae1%e4%be%8b.pdf13450069AA11252383Journal of Nara Medical Association5032632661999-06-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/5242017-05-29T06:06:54Zhdl_10564_1531急性心筋炎治療中に薬物性急性間質性腎炎・急性問質性肺炎を発症した高齢者の1例A CASE OF DRUG-INDUCED ACUTE INTERSTITIAL NEPHRITIS AND ACUTE INTERSTITIAL PNEUMONITIS IN THE COURSE OF ACUTE MYOCARDITIS原田, 幸児山野, 繁濱野, 一將西本, 和央中嶋, 民夫川本, 篤彦坂口, 泰弘椎木, 英夫土肥, 和紘amiodaronedrug-induced acute interstitial nephritisdrug-induced acute interstitial pneumonitisindomethacinA case of drug-induced acute interstitial nephritis and acute interstitial
pneumonitis in the course of acute myocarditis is reported. A 75-year-old woman was
admitted to our hospital on December 8, 1997 with a 2-week history of exertional dyspnea.
She was in atrial fibrillation with a rapid ventricular rate. The chest X-ray film showed
cardiomegaly (cardiothoracic ratio: 61.6%) and severe pulmonary congestion. The
electrocardiogram showed poor R progression in leads V 1-4 and negative T waves in leads
V 5-6. Echocardiogram showed asynergy of the anterior wall and a large amount of
pericardial effusion. Coronary angiogram revealed normal coronary arteries, and myocar-
dial biopsy showed the features of acute myocarditis. She remained in rapid atrial fibrilla-
tion, so oral amiodarone hydrochloride 400 mg was started on December 14, 1997, reducing
to 200 mg daily. She had both knee arthralgia, and was diagnosed as having gonarthrosis.
Oral indomethacin farnesil was started at 400 mg daily. One day later, nausea and
abdominal pain occurred. The blood urea nitrogen and the serum creatinine were elevated
(36 and 3.1 mg/dl), the chest X-ray film showed severe pulmonary congestion, and 67 Ga-
citrate scintigram showed increased 67 Ga-citrate uptake in both kidneys. Therefore, acute
renal failure due to drug-induced interstitial nephritis was diagnosed and hemodialysis was
started. One hundred and forty days after amiodarone hydrochloride was started, severe
dyspnea appeared. Chest computed tomography showed the changes of drug-induced acute
interstitial pneumonia, so her amiodarone hydrochloride therapy was stopped.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.50 No.3 p.267-27213450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/524Journal of Nara Medical Association, 50(3): 267-272http://hdl.handle.net/10564/524http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/524/1/267-272p.%e6%80%a5%e6%80%a7%e5%bf%83%e7%ad%8b%e7%82%8e%e6%b2%bb%e7%99%82%e4%b8%ad%e3%81%ab%e8%96%ac%e7%89%a9%e6%80%a7%e6%80%a5%e6%80%a7%e9%96%93%e8%b3%aa%e6%80%a7%e8%85%8e%e7%82%8e.pdf13450069AA11252383Journal of Nara Medical Association5032672721999-06-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/5252017-05-29T06:06:52Zhdl_10564_1531横紋筋融解症を頻回に発症した1剖検例AN AUTOPSY CASE OF RHABDOMYOLYSIS WITH REPETITIVE MYOLYSIS EPISODES田宮, 正章金内, 雅夫栗岡, 英行水野, 麗子中谷, 秀隆松田, 尚史椎木, 英夫土肥, 和紘藤本, 眞一中野, 博美島, 健二市島, 國雄村田, 顕也acute renal failurerhabdomyolysisviral infectionA sixty-year-old male was admitted to our hospital because of myalgia.
He had been admitted to our hospital four times due to similar myalgia episodes after flu
-like symptoms. The diagnosis of rhabdomyolysis was made by laboratory data which
showed severe elevation in serum level of creatine kinase and myoglobin. On the fourth
hospital day, he died from heart failure following acute renal failure, although hemodialysis
had been started. Autopsy was performed and revealed myolysis, but no other evidence to
confirm the mechanism of rhabdomyolysis in the present case. Repetitive myolysis episodes
could also occur in patients with rhabdomyolysis.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.50 No.3 p.273-27613450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/525Journal of Nara Medical Association, 50(3): 273-276http://hdl.handle.net/10564/525http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/525/1/273-276p.%e6%a8%aa%e7%b4%8b%e7%ad%8b%e8%9e%8d%e8%a7%a3%e7%97%87%e3%82%92%e9%a0%bb%e5%9b%9e%e3%81%ab%e7%99%ba%e7%97%87%e3%81%97%e3%81%9f1%e5%89%96%e6%a4%9c%e4%be%8b.pdf13450069AA11252383Journal of Nara Medical Association5032732761999-06-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/5262017-05-29T06:06:54Zhdl_10564_1531糖尿病と下垂体機能障害を合併し,高度の痴呆を呈したKlinefelter症候群の1例A CASE OF KLINEFELTER'S SYNDROME ASSOCIATED WITH DIABETES MELLITUS, PITUITARY GLAND DYSFUNCTION, AND SEVERE DEMENTIA葛本, 雅之鎌田, 勝三郎中江, 恵美子藤本, 伸一藤井, 謙裕椎木, 英夫藤本, 眞一金内, 雅夫土肥, 和紘dementiadiabetes mellitusKlinefelter's syndromepituitary gland dysfunctionWe report a case of Klinefelter's syndrome associated with diabetes
mellitus, pituitary gland dysfunction, and severe dementia. The patient was a 70-year-old
man who had been under medical treatment for diabetes mellitus for twenty years. In
March 1998, he developed cerebral infarction and symptoms of dementia. Physical exami-
nation revealed projection of both forehead and lower jaw, hypoplasia of the genitals, and
blood flow insufficiency beyond the bilateral popliteal arteries. Chromosomal analysis
showed a 46, XY/46, XX/47, XXY mosaic pattern. HbA1c rose to 8.4% and ΔIRI/ΔBS was
0.02 ng/ml, indicating decreased insulin secretion. A pituitary gland dysfunction compli-
cated the clinical scenario in this patient, the secretion of growth hormone, adrenocor-
ticotropic hormone, prolactin, and cortisol was increased, and that of luteinizing hormone,
follicle-stimulating hormone, and testosterone was decreased. Magnetic resonance images
of the head showed a normal-appearing pituitary gland and cerebral infarction at both the
middle and posterior cerebral artery. Therefore, our patient was considered to have
vascular dementia.
In this report, we discuss the relationship between Klinefelter's syndrome and either
diabetes mellitus or pituitary gland dysfunction.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdfJournal of Nara Medical Association Vol.50 No.3 p.277-28513450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/526Journal of Nara Medical Association, 50(3): 277-285http://hdl.handle.net/10564/526http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/526/1/277-285p.%e7%b3%96%e5%b0%bf%e7%97%85%e3%81%a8%e4%b8%8b%e5%9e%82%e4%bd%93%e6%a9%9f%e8%83%bd%e9%9a%9c%e5%ae%b3%e3%82%92%e5%90%88%e4%bd%b5%e3%81%97%2c%e9%ab%98%e5%ba%a6%e3%81%ae%e7%97%b4%e5%91%86%e3%82%92%e5%91%88%e3%81%97%e3%81%9fKlinefelter%e7%97%87%e5%80%99%e7%be%a4%e3%81%ae1%e4%be%8b.pdf13450069AA11252383Journal of Nara Medical Association5032772851999-06-30jpnpublisher