2024-03-28T15:55:31Zhttp://ginmu.naramed-u.ac.jp/dspace-oai/request
oai:ginmu.naramed-u.ac.jp:10564/11352017-05-29T06:07:02Zhdl_10564_1496企業労働者の精神健康度調査A PSYCHIATRIC SURVEY OF PRIVATE COMPANY EMPLOYEES織部, 裕明mental healthGHQZung Self Rating Depression Scalecompany employeeThe psychiatric health of employees of a large company was assessed using
two scales (GHQ, ZDS). The subjects comprised 655 employees (480 males, 175 females ;
mean age 42.7 years). Findings are summarized as follows : 1) Significant correlation was
noted between GHQ and ZDS scores. 2) For the entire study population, 23.8% of the
subjects had a tendency toward neurosis, as rated by GHQ, and 35.0% had a tendency
toward depression, as rated by ZDS. Regarding sex difference, a tendency toward neurosis
was significantly more often noted in females than in males. 3) Degree of subjective
dissatisfaction with job significantly correlated with both tendencies. 4) Regarding job
type, the tendencies toward neurosis and depression were significantly less often noted in
engineers and workers less involved in customer reception than in clerical employees and
workers mainly in charge of customer reception. 5) The tendencies toward neurosis and
depression were significantly less often noted in subjects who took 30 ml of alcohol (about
180 ml of Japanese sake) daily than in subjects who took no alcohl, and who took 60 ml
(about 360 ml of Japanese sake) or more daily. 6) The tendencies toward neurosis and
depresson were less often noted in subjects living with four family members than in those
living with another number of family members.
Further investigation will be needed to determine ways of improving job satisfaction, and
to clarify the relationship between family composition and stress.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paperapplication/pdf奈良医学雑誌 Vol.46 No.5 p.487-4990469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/1135奈良医学雑誌, 46(5): 487-499http://hdl.handle.net/10564/1135http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/1135/3/487-499p.%e4%bc%81%e6%a5%ad%e5%8a%b4%e5%83%8d%e8%80%85%e3%81%ae%e7%b2%be%e7%a5%9e%e5%81%a5%e5%ba%b7%e5%ba%a6%e8%aa%bf%e6%9f%bb.pdf04695550AN00180974奈良医学雑誌4654874991995-10-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29122017-06-11T23:20:26Zhdl_10564_1496表紙、目次、訂正、投稿規程、奥付(Vol.46 No.5)表紙目次投稿規定奥付奈良医学会奈良県立医科大学OtherOthers奈良医学雑誌 Vol.46 No.50469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2912奈良医学雑誌, 46(5)http://hdl.handle.net/10564/2912http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2912/3/000p.%e8%a1%a8%e7%b4%99%e3%80%81%e7%9b%ae%e6%ac%a1%e3%80%81%e8%a8%82%e6%ad%a3%e3%80%81%e6%8a%95%e7%a8%bf%e8%a6%8f%e5%ae%9a%e3%80%81%e5%a5%a5%e4%bb%98%28Vol.46_No.5%29.pdf04695550AN00180974奈良医学雑誌4651995-10-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29132017-05-29T06:08:24Zhdl_10564_1496境界例すなわち分裂病型人格障害のロールシャッハ研究 : 血友病A, HIV感染症の一症例THE RORSCHACH TEST AND DIAGNOSIS OF SHIZOTYPAL PERSONALITY DISORDER : A CASE STUDY岸本, 年史川端, 洋子田原, 宏一松本, 寛史森, 治樹井川, 玄朗schizotypal personality disorderhemophilia Ahuman immunodeficiency virus (HIV)AIDSRorschach testA hemophiliac patient had suffered from episodic psychotic symptoms. He was diagnosed as having a schizotypal personality disorder based on DSM-IV. After human immunodeficiency virus (HIV) infection, his psyehotic symptoms disappeared and he adjusted himself to his environment better than before. At the age of 23, he was tested with the Rorschach test and was studied from psychological developmental viewpoints. His immature perception suggested that his ego developmental level remained in the separation individuation phase.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.5 p.329-3370469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2913奈良医学雑誌, 46(5): 329-337http://hdl.handle.net/10564/2913http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2913/1/329-337p.%e5%a2%83%e7%95%8c%e4%be%8b%e3%81%99%e3%81%aa%e3%82%8f%e3%81%a1%e5%88%86%e8%a3%82%e7%97%85%e5%9e%8b%e4%ba%ba%e6%a0%bc%e9%9a%9c%e5%ae%b3%e3%81%ae%e3%83%ad%e3%83%bc%e3%83%ab%e3%82%b7%e3%83%a3%e3%83%83%e3%83%8f%e7%a0%94%e7%a9%b6.pdf04695550AN00180974奈良医学雑誌4653293371995-10-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29142017-06-11T23:20:26Zhdl_10564_1496QUALITY OF LIFE IN PATIENTS WITH DIABETES MELLITUSKanauchi, MasaoNishioka, HisayukiYashima, IsaoKikawa, TadatoshiAkai, MayumiKawano, TakahiroIshii, KenjiNakashima, YasuoHirayama, ToshihideNishiura, KimiakiMatsumoto, YoshitakaHashimoto, ToshioDohi, Kazuhirodiabetes mellitusinsulin therapyquality of lifeWe evaluated the quality of life (QOL) in 268 patients with diabetes mellitus (NIDDM, 250 cases; IDDM, 10 cases; and other type of diabetes, 8 cases) to determine which aspects were adversely affected by the disease. Information concerning life satisfaction, social activities, ability to work, sexual problems and physical symptoms was obtained from a 30-item questionnaire. Clinical characteristics including duration of diabetes, glycemic control, current treatment, obesity, hypertension, hyperlipidemia, macro- and microvascular complications were obtained from medical records. Diminished QOL was most pronounced in patients who had had a long duration of disease, required insulin therapy, and whose health was disturbed by cerebrovascular disease, end-stage renal disease, mono- and autonomic neuropathy. A significant difference in the subdimensional QOL score was noted in life satisfaction, social activities, ability to work, sexual problems and physical symptoms under these circumstances.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.5 p.338-3450469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2914奈良医学雑誌, 46(5): 338-345http://hdl.handle.net/10564/2914http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2914/1/338-345p.QUALITY_OF_LIFE_IN_PATIENTS_WITH_DIABETES_MELLITUS.pdf04695550AN00180974奈良医学雑誌4653383451995-10-31engpublisher
oai:ginmu.naramed-u.ac.jp:10564/29152017-05-29T06:08:20Zhdl_10564_1496腸重積症で初発したS状結腸癌の2例TWO CASES OF SIGMOID CANCER WITH INTUSSUSCEPTION松下, 和広東野, 正奥田, 浩史川本, 博熨斗, 秀興白山, 泰明則武, 正三豊川, 元邦岩井, 均池中, 康英佐藤, 由美子松為, 裕二諏訪, 好信小泉, 雅紀松村, 圭祐松本, 真高谷, 章福井, 博辻井, 正intussusceptionsigmoid colon cancerTwo-thirds of adult patients with intussusception are reported to have enterointestinal tumors. We experienced two cases of sigmoid colon cancer. Two female patients, aged 54 and 32, presented with severe lower abdominal pain and melena. The rectal examination revealed the presence of a hen-egg-sized tumor with bloody discharge in both patients. To determine the cause of persistent lower abdominal pain, we performed computed tomography(CT) scans, which showed sigmoid-rectal intussusception. Barium studies and colonoscopy disclosed that intussusception was caused by sigmoid cancer of Borrmann typeⅠ. These cases suggest that CT scan may be useful for rapid diagnosis of sigmoid-rectal intussusception due to tumors in patients presenting with severe lower abdomiminal pain.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.5 p.346-3510469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2915奈良医学雑誌, 46(5): 346-351http://hdl.handle.net/10564/2915http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2915/1/346-351p.%e8%85%b8%e9%87%8d%e7%a9%8d%e7%97%87%e3%81%a7%e5%88%9d%e7%99%ba%e3%81%97%e3%81%9fS%e7%8a%b6%e7%b5%90%e8%85%b8%e7%99%8c%e3%81%ae2%e4%be%8b.pdf04695550AN00180974奈良医学雑誌4653463511995-10-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29192017-05-29T06:08:37Zhdl_10564_1496哺乳類骨格筋における毛細血管分布について : 特に筋線維の代謝,機能特性に関連してMORPHOMETRIC ANALYSIS OF CAPILLARITY IN MAMMALIAN SKELETAL MUSCLES : WITH SPECIAL REFERENCE TO METABOLIC AND FUNCTIONAL PROPERTIES OF MUSCLE FIBRES森本, 委利capillaryskeletal musclemammaldiffusiondivingFrozen sections of skeletal muscles were histochemically stained for capillaries by an amylase-PAS procedure and for histochemical typing of muscle fibres by a myofibrillar ATPase method in autopsy samples from 9 mammalian species : Norway rat, squirrel monkey, racoon dog, nutria, blackbuck, red kangaroo, western grey kangaroo, California sea lion and western lowland gorilla. Using a computer-aided image-analysing procedure the capillarities of the muscles were analysed by means of the "capillary domain area (CDA)", muscular cross area diffusionally governed by one capillary, and the Kroghian radius (Rᴋ) computed therefrom. Myoglobin contents (Mb) of the muscles were spectrophotometrically determined. As for the CDA (Rᴋ) we found evident species difference, muscle difference in any one species, and also regional difference in any one muscle, the facts suggesting that the capillarity might reflect functional and metabolic characteristics of muscles. We found also that the capillarity was highly correlated with muscle fibre cross area (FA) and Mb, and less and reciprocally correlated with oxidative muscle fibre contents in the muscle. California sea lion, a long-diving mammal, was quite different from the other 8 terrestrial species in that it exhibited much higher Mb and much poorer capillary supply. All these special characters could be reasonably understood in view of its diving behavior, in which, during diving, the blood supply to the muscles is almost completely cut off and the metabolic property swings rapidly from oxidative to glycolytic.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.5 p.352-3670469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2919奈良医学雑誌, 46(5): 352-367http://hdl.handle.net/10564/2919http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2919/1/352-367p.%e5%93%ba%e4%b9%b3%e9%a1%9e%e9%aa%a8%e6%a0%bc%e7%ad%8b%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e6%af%9b%e7%b4%b0%e8%a1%80%e7%ae%a1%e5%88%86%e5%b8%83%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6.pdf04695550AN00180974奈良医学雑誌4653523671995-10-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29202017-05-29T06:08:18Zhdl_10564_1496ラット骨格筋ミオグロビンの単離と諸特性ISOLATION AND PROPERTIES OF MYOGLOBIN FROM SKELETAL MUSCLES OF RAT (RATTUS NORVEGIGUS)服部, 雅俊ratmyoglobinprimary structuremixed disulfidesoxygenationMyoglobin was isolated and purified by heat denaturation-gel filtrationchromatofocusing procedure from water extract of skeletal muscles of the rat. One major (fraction Ⅰ) and two minor (fractions Ⅱ and Ⅲ) omponents were finally obtained. Amino acid sequence of the major component was determined by an automatic Edman degradation procedure. As compared with murine myoglobin, we found amino acid replacements at 9 positions. Cysteine residue, with sulfhydryl group highly reactive to p-chloromercuribenzoate (PMB), was present at position 66 in both rat and murine myoglobins. The two minor components with higher anodic electrophoretic mobilities and with sulfhydryl group unreactive to PMB were found to be derived through mixed disulfide formation with cysteine (component Ⅱ) or glutathione (component Ⅲ) at the 66th cysteine residue of the major component. In view of the hydropathy profile, secondary structures of rat and murine myoglobins were little different from each other and a prominent hydrophobic lobe around position 70, corresponding to the E-helix containing the distal histidine residue at position 64, was noted. The three components showed essentially identical oxygen equilibrium properties with neither homotropic nor heterotropic allosteric interactions. Halfoxygenation pressure (P₅₀) of the proteins calculated from the kinetic measurements, assuming a simple bimolecular reaction model, agreed very well with those determined by oxygen equilibria.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.5 p.368-3780469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2920奈良医学雑誌, 46(5): 368-378http://hdl.handle.net/10564/2920http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2920/1/368-378p.%e3%83%a9%e3%83%83%e3%83%88%e9%aa%a8%e6%a0%bc%e7%ad%8b%e3%83%9f%e3%82%aa%e3%82%b0%e3%83%ad%e3%83%93%e3%83%b3%e3%81%ae%e5%8d%98%e9%9b%a2%e3%81%a8%e8%ab%b8%e7%89%b9%e6%80%a7.pdf04695550AN00180974奈良医学雑誌4653683781995-10-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29232017-06-11T23:20:26Zhdl_10564_1496VENTRICULAR ENLARGEMENT AND WATER INTOXICATION IN SCHIZOPHRENIAKishimoto, ToshifumiMatsumura, KazuyaKurata, SetsukoHirai, MotoharuYamaoka, KazueMatsuoka, IzuruMiyake, MasakazuIkawa, GenroIwasaki, SatoruNakane, Masatoschizophreniawater intoxicationpolydipsiahyponatremiaventricular enlargementTo determine the extent to which atrophy was related to water intoxication in schizophrenic patients, ventricular enlargement in polydipsic schizophrenic patients with hyponatremia and schizophrenic controls without hyponatremia was measured in a linear way. Ventricular enlargement was found in both schizophrenic patient groups, and larger ventricles were associated with water intoxication. It is suggested that ventricular enlargement may reflect a developmental or degenerative pathological process involving the occurrence of water intoxication in schizophrenia.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.5 p.379-3830469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2923奈良医学雑誌, 46(5): 379-383http://hdl.handle.net/10564/2923http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2923/1/379-383p.VENTRICULAR_ENLARGEMENT_AND_WATER_INTOXICATION.pdf04695550AN00180974奈良医学雑誌4653793831995-10-31engpublisher
oai:ginmu.naramed-u.ac.jp:10564/29242017-06-11T23:20:26Zhdl_10564_1496SUCCESSFUL TREATMENT OF OBSESSIVE-COMPULSIVE DISORDER WITH ELECTROCONVULSIVE THERAPYKishimoto, ToshifumiIkawa, Genroelectroconvulsive therapyobsessive-compulsive disorderTwo men with obsessive-compulsive disorder showed abnormal behaviors including agitation and aggression without evidence of depression. They responded to electroconvulsive therapy (ECT) following failure of drug treatments. Further investigation of the utility of ECT in treating drug refractory obsessive-compulsive disorder is indicated.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.5 p.384-3880469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2924奈良医学雑誌, 46(5): 384-388http://hdl.handle.net/10564/2924http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2924/1/384-388p.SUCCESSFUL_TREATMENT_OF_OBSESSIVE-COMPULSIVE_DISORDER.pdf04695550AN00180974奈良医学雑誌4653843881995-10-31engpublisher
oai:ginmu.naramed-u.ac.jp:10564/29252017-06-11T23:20:26Zhdl_10564_1496PREVENTION OF MYOCARDIAL DAMAGE IN BIO 14.6 STRAIN OF CARDIOMYOPATHIC HAMSTERS BY DENOPAMINESutani, ToshioBIO 14.6 hamsterdenopaminebeta-adrenergic receptoradenylate cyclasecAMPDenopamine, which is an oral1y effective cardiotonic agent and a beta-1-receptor-selective agonist, reportedly prolongs the survival of the BIO 14.6 strain of cardiomyopathic Syrian hamsters(BIO). The latter is an animal model of human idiopathic cardiomyopathy. The purpose of the present experiment was to investigate the effects of denopamine on myocardial damage in BIO hamsters. They were divided into two groups: one that received denopamine treatment (1 mg/kg/day) from 2months of age, and a control (untreated) group. Morphological studies of the myocardium, assays for beta-adrenergic receptors, and measurements of myocardial adenylate cyclase (AC) activity and cAMP concentration were performed at 1,3, and 7months of age in al1 animals. It was observed that denopamine: 1) inhibited the progression of disease from the stage of hypertrophy to that of congestive failure that was demonstrated in the control BIO hamster, 2) inhibited the down-regulation of beta-1-adrenergic receptors in the myocardium of the control BIO hamsters at 7months of age, and 3) prevented an increase in myocardial AC activity and cAMP concentration that was seen in control BIO hamsters at 3months of age (stage of ealy hypertrophy). In conclusion, denopamine may prevent myocardial damage in BIO hamsters by inhibiting the down-regulation of beta-1-adrenergic receptors,thus preventing an increase in myocardial AC activity and cAMP concentration.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.5 p.389-3960469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2925奈良医学雑誌, 46(5): 389-396http://hdl.handle.net/10564/2925http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2925/1/389-396p.PREVENTION_OF_MYOCARDIAL_DAMAGE.pdf04695550AN00180974奈良医学雑誌4653893961995-10-31engpublisher
oai:ginmu.naramed-u.ac.jp:10564/29262017-05-29T06:08:59Zhdl_10564_1496単純へルペスウイルス由来チミジンキナーゼ遺伝子の肝癌細胞特異的発現に基づく肝癌に対する遺伝子治療の基礎的研究BASIC INVESTIGATIONS OF GENE THERAPY FOR HEPATOMA BASED UPON HEPATOMA CELL-SPECIFIC EXPRESSION OF THE HERPES SIMPLEX VIRUS THYMIDINE KINASE GENE阪本, たけみgene therapyhepatomaherpes simplex virus thymidine kinasealbumin gene promoterretroviral vectorFeasibility of gene therapy for hepatoma based upon hepatoma-cell specific expression of the herpes simplex virus thymidine kinase (HSV-tk) gene was investigated. Alb e/p-pNT 230 retroviruses, which contain the HSV-tk gene under the transcriptional control of the murine albumin gene enhancer and promoter, were produced from ecotropic Psi 2 retroviral packaging cells. Infection of Alb e/p-pNT 230 retroviruses to hepatoma cells did not affect the cell proliferation at all. The retroviral-infected hepatoma cells, however, were susceptible to ganciclovir and acyclovir toxicity, while uninfected parental hepatoma cells were not. Ganciclovir was proven to exhibit much stroner cytotoxicity upon the retroviral-infected hepatoma cells than acyclovir. On the other hand, Alb e/p-pNT 230 retroviral-infected non-hepatoma cells were resistant to ganciclovir, and the sensitivity was more than 100-fold different as compared with the same retroviral-infected hepatoma cells, indicating the potential of hepatoma cell-specific elimination without affecting any other tissues by use of Alb e/p-pNT 230 retroviruses. Furthermore, when mice bearing a bulky established tumor consisting of Alb e/p-pNT 230 retroviral-infected hepatoma cells were treated with ganciclovir, complete tumor regression was observed in 11 of 14 mice. These results indicate the feasibility of gene therapy for heptoma using the HSV-tk and ganciclovir system. Finally, 3ganciclovir-resistant clones were established from 3tumors that were not abrogated by ganciclovir treatment. These clones were proven not to lose the HSV-tk gene transferred by Alb e/p-pNT 230 retroviruses. The gene was, however, heavily methylated, and 5-azacytidine treatment partially restored the sensitivity of these 3clones to ganciclovir, indicating that methylation plays an essential role in expression of the retrovirally transferred gene.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.5 p.397-4100469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2926奈良医学雑誌, 46(5): 397-410http://hdl.handle.net/10564/2926http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2926/1/397-410p.%e5%8d%98%e7%b4%94%e3%81%b8%e3%83%ab%e3%83%9a%e3%82%b9%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%e7%94%b1%e6%9d%a5%e3%83%81%e3%83%9f%e3%82%b8%e3%83%b3%e3%82%ad%e3%83%8a%e3%83%bc%e3%82%bc%e9%81%ba%e4%bc%9d%e5%ad%90.pdf04695550AN00180974奈良医学雑誌4653974101995-10-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29272017-05-29T06:08:19Zhdl_10564_1496ハイリスク乳幼児の気質特徴に関する研究 : 奈良県立医科大学附属病院新生児集中治療部で管理を受けた34例の3歳時点での評価A STUDY ON TEMPERAMENTAL CHARACTERISTICS OF HIGH RISK INFANTS : EVALUATION AT 36 MONTHS OF AGE, ON 34 INFANTS WHO WERE ADMITTED TO THE NEONATAL INTENSIVE CARE UNIT, NARA MEDICAL UNIVERSITY HOSPITAL田原, 宏一temperamental characteristicsJTTShigh risk infantdevelopmental quotientJHSQThe purpose of this study was to assess temperamental characteristics at 36 months of age of high risk infants, and to clarify the relationship between temperamental characteristics and risk factors. Subjects were 34 infants, at 36 months of age, who had been admitted to the Neonatal Intensive Care Unit (NICU) at Nara Medical University Hospital. They were assessed for risk factors, developmental quotient (DQ) and home environment estimated by Japanese Home Screening Questionnaire (JHSQ). Temperamental characteristics were assessed by using the Japanese edition of Toddler Temperament Scale. The results were as follows: (1) In comparison with the normal control group, the high risk group showed higher category scores of approach, adaptability, intensity and persistence, but showed lower category scores of threshold. The prevalence of the difficult child was relatively higher, and that of the easy child was lower in the high risk group. (2) In any of the risk factors, maternal occupation, life with grandparents, socioeconomic status, hereditary tendency of mental disorder, problems of paments' personalities, problems of maternal past illriess, stress, birth weight, toxemia of pregnancy, abnormality of amniotic fluid, neonatal pulmonary disease, neonatal heart disease, neonatal anemia and neonatal hypoglycemia had an influence on the temperament scores in the high risk group. (3) DQc orrelated with category scores of adaptability, persistence, and threshold. (4) Home environment of subjects correlated with category score of intensity.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.5 p.411-4220469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2927奈良医学雑誌, 46(5): 411-422http://hdl.handle.net/10564/2927http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2927/1/411-422p.%e3%83%8f%e3%82%a4%e3%83%aa%e3%82%b9%e3%82%af%e4%b9%b3%e5%b9%bc%e5%85%90%e3%81%ae%e6%b0%97%e8%b3%aa%e7%89%b9%e5%be%b4%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8b%e7%a0%94%e7%a9%b6.pdf04695550AN00180974奈良医学雑誌4654114221995-10-31publisher
oai:ginmu.naramed-u.ac.jp:10564/29282017-05-29T06:08:20Zhdl_10564_1496精神遅滞児の認知発達段階と問題行動に関する研究A STUDY OF COGNITIVE DEVELOPMENT AND BEHAVIOR PROBLEMS IN MENTALLY RETARDED CHILDREN橋野, 健一cognitive developmentbehavior problemsmental retardationautismsymbolic functionSeventy-one mentally retarded childen (19 autistic, 52 non-autistic ; age 7-19 years) from a school for handicapped childen were studied as to cognitive development, using Ohta's scale for evaluating cognitive development level based on language comprehension (Ohta's stage) and other developmental scales. Behavior problems were also examined. Ohta et al. have reported that Ohta's scale is valid and useful in evaluating cognitive development in autistic children. The present paper reports on the utility of Ohta's stage in non-autistic children, and the relationship between cognitive development level and behavior problems in mentally retarded children. Findings are summarized as follows : 1) In non-autistic children, there was a temporal correlation between Ohta's stage and other developmental scales (standard developmental tests, speech development, symbolic play development), suggesting that in non-autistic children as well, Ohta's stage may serve well as a scale for cognitive development, and reflect symbolic representational functioning. 2) Development of symbolic play and imitation lagged behind development of language in some autistic children. On the other hand, there was concordance between development of symbolic play and imitation, and development of language, in all non-autistic children. 3) Non-autistic children of lower cognitive development level more often exhibited stereotypic behaviors and hyperkinesis. On the other hand, ritualistic and compulsive behaviots were noted in non-autistic children, irrespective of cognitive development level. The relation between these behavior problem and the cognitive development level found in non-autistic children was similar to the relation that has been reported in autistic children. 4) With regard to the entire study population, most behavior problems in feeding, elimination and sleeping were closely associated with cognitive development level, and were more often noted in children of lower cognitive development level. Some behavior problems may often occur in the sensorimotor period and hardly occur in the symbolic representational period.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.5 p.423-4380469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2928奈良医学雑誌, 46(5): 423-438http://hdl.handle.net/10564/2928http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2928/1/423-438p.%e7%b2%be%e7%a5%9e%e9%81%85%e6%bb%9e%e5%85%90%e3%81%ae%e8%aa%8d%e7%9f%a5%e7%99%ba%e9%81%94%e6%ae%b5%e9%9a%8e%e3%81%a8%e5%95%8f%e9%a1%8c%e8%a1%8c%e5%8b%95%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8b%e7%a0%94%e7%a9%b6.pdf04695550AN00180974奈良医学雑誌4654234381995-10-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29292017-06-11T23:20:26Zhdl_10564_1496Rhodamine123のヒト由来前立腺癌培養細胞の増殖に及ぽす影響に関する研究EFFECTS OF RHODAMINE 123 ON THE CELL GROWTH OF HUMAN PROSTATE CARCINOMA CELLS IN VITRO AND IN VIVO吉江, 貫rhodamine 123cell growthhuman prostate carcinoma cells2-deoxy-D-glucosemethylglyoxal bis (guanylhydrazone)A lot of novel chemotherapeutic agents have been developed recently, improving the management of urogenital carcinomas. However, effective chemotherapy has not yet been established for advanced renal cell carcinoma and hormone relapsing prostate carcinoma. Most of the chemotherapeutic agents target DNA in tumor cells; therefore, the new agents functioning in different mechanisms to inhibit tumor cell growth are expected for the treatment of these carcinomas. Rhodamine 123 (Rh), a red fluorescent dye, has the property to acummulate more and be retained longer in the mitochondria of malignant transformed cells than in those of normal cells. In this study, the suppressive effect of Rh on the growth of cultured prostate carcinoma cells (PC-3 and LNCaP) was examined in vitro and in vivo. Rh suppressed the growth of PC-3 and LNCaP cells significantly. The accumulation and retention of Rh in PC-3 cells was demonstrated both in vitro and in PC-3 tumor cel1s implanted in nude mice. Methylglyoxal Bis(guanylhydrazone) (MGBG) and 2-deoxy-D-glucose (2DG) suppressed the growth of PC-3 and LNCaP cells when each was administered in combination with Rh ; namely, these agents seem to modulate the suppressing effect of Rh on the growth of tumor cells. These results indicate that Rh has the potential to be an anticancer agent against prostate carcmomas.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.5 p.439-4520469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2929奈良医学雑誌, 46(5): 439-452http://hdl.handle.net/10564/2929http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2929/1/439-452p.Rhodamine_123%e3%81%ae%e3%83%92%e3%83%88%e7%94%b1%e6%9d%a5%e5%89%8d%e7%ab%8b%e8%85%ba%e7%99%8c%e5%9f%b9%e9%a4%8a%e7%b4%b0%e8%83%9e.pdf04695550AN00180974奈良医学雑誌4654394521995-10-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29302017-05-29T06:08:59Zhdl_10564_1496児童期発症精神分裂病の特徴と前駆期の強迫症状の有無による下位分類に関する検討THE CHARACTERISTICS OF CHILDHOOD-ONSET SCHIZOPHRENIA AND A STUDY OF CLASSIFICATION INTO SUBTYPES ACCORDING TO THE PRESENCE OR ABSENCE OF OBSESSIVE-COMPULSIVE SYMPTOMS IN THE PRODROMAL PHASE松村, 一矢childhood-onsetschizophreniaprodromal symptomsobsessive-compulsive symptomsPatients with childhood-onset schizophrenia frequently show obsessive-compulsive symptoms in the prodromal phase. The aim of this study was to investigate the differences between the characteristics of schizophrenia with and without obsessive-compulsive symptoms in the probromal phase. Findings are summarized as follows : 1) Of patients with schizophrenia diagnosed by the DSM-Ⅲ-R, 50 who developed the disease at under 15 years of age (childhood-onset group) and 35 who developed the disease at over 20 years of age (adulthood-onset group) were compared. The childhood-onset group was found to include many subjects who developed obsessive-compulsive symptoms in the prodromal phase (21/50) ; prevalent clinical symptoms were poverty of speech, magical thinking, lability of mood and delusion of observation ; less prevalent clinical symptoms were auditory hallucination and delusion of persecution. 2) Subjects in the childhood-onset group were subdivided into 21 subjects who developed obsessive-compulsive symptoms in the prodromal phase (childhood-onset (+) group) and 29 without obsessive-compulsive symptoms (childhood-onset (-) group). Comparison was made between the two groups and with the adulthood-onset group. Males accounted for the majority of the childhood-onset (+) group (20/21). Other parameters involving major group-to-group differences were onset type, brain CT findings, family history of psychotic disorders, premorbid personality, clinical symptoms, and Global Assessment of Functioning Scale (GAF Scale) score at 3 years after onset. These findings suggest the possibility of classifying childhood-onset schizophrenia into subtypes according to the presence or absence of obsessive-compulsive symptoms in the prodromal phase.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.5 p.453-4630469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2930奈良医学雑誌, 46(5): 453-463http://hdl.handle.net/10564/2930http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2930/1/453-463p.%e5%85%90%e7%ab%a5%e6%9c%9f%e7%99%ba%e7%97%87%e7%b2%be%e7%a5%9e%e5%88%86%e8%a3%82%e7%97%85%e3%81%ae%e7%89%b9%e5%be%b4%e3%81%a8%e5%89%8d%e9%a7%86%e6%9c%9f%e3%81%ae%e5%bc%b7%e8%bf%ab%e7%97%87%e7%8a%b6.pdf04695550AN00180974奈良医学雑誌4654534631995-10-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29312017-06-11T23:20:26Zhdl_10564_1496腎細胞癌におけるBasic Fibroblast Growth Factorの腫瘍マーカーとしての有用性の研究POTENTIAL USEFULNESS OF BASIC FIBROBLAST GROWTH FACTOR AS A TUMOR MARKER FOR RENAL CELL CARCINOMA山口, 尚子藤本, 清秀大園, 誠一郎平尾, 佳彦岡島, 英五郎市森, 有三basic fibroblast growth factorenzyme immunoassayrenal cell carcinomatumor markerurogenital canceSerum levels of basic fibroblast growth factor (FGF) by enzyme immunoassay in patients with various urogenital tumors were examined in the present investigation. The incidence of renal cell carcinoma with increased serum levels of basic FGF (28 of 52, 53.8%) was significantly higher than those of any other urogenital tumors such as bladder cancer (6 of 26, 23.1%), testicular tumor (0 of 12, 0%) and prostatic cancer (2 of 7, 28.6%). Increased serum basic FGF was detected more frequently in patients with advanced renal cell carcinoma, stage pT3, grade G2. Analysis of histopathological pattern indicated that renal cell carcinoma with a solid or tubular component had a higher tendency of increased serum basic FGF. However, no significant difference was seen in the incidence of patients with increased serum basic FGF between c1ear cell subtype group (18 of 36, 50.0%) and granular cell subtype group (4 of 6, 66.7%). Thus, increase of serum basic FGF does not appear to depend on the cell type. Serum basic FGF may be produced and secreted from tumor tissue with pathologically high grade malignancy. Forty-five resected renal cell carcinomas were divided into two groups based on the maximum diameter of the primary tumor: ≧ 5cm and < 5cm; there was not a significant difference between these two groups. Five of 8 patients with renal cell carcinoma who underwent selective renal venous sampling before operation showed increased serum basic FGF in the renal vein from the affected kidney. After resection of the affected kidney, serum basic FGF disappeared within 2 weeks. However, residual huge tumor or postoperative disease prolonged the increased levels of serum basic FGF in 2 patients, indicating that serum basic FGF is produced from and secreted by tumor tissue itself. These findings may suggest that serum basic FGF can be a useful tumor marker in patients with renal cell carcinoma.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.5 p.464-4760469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2931奈良医学雑誌, 46(5): 464-476http://hdl.handle.net/10564/2931http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2931/1/464-476p.%e8%85%8e%e7%b4%b0%e8%83%9e%e7%99%8c%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bBasic_Fibroblast_Growth_Factor.pdf04695550AN00180974奈良医学雑誌4654644761995-10-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29322017-06-11T23:20:26Zhdl_10564_1496マウスMycobacterium intracellulare感染におけるサイトカイン産生動態と抵抗性ROLE OF CYTOKINES IN EXPRESSION OF INNATE RESISTANCE AND SUSCEPTIBILITY TO MYCOBACTERIUM INTRACELLULARE INFECTIONS IN MICE松井, 則夫M.intracellulareMAC infectioncytokinesIL-4IL-10RT-PCRThe purpose of this study was to better the sequence of cytokine mRNA expression during the infectious course of Mycobacterium intracellulare, belonging to Mycobacterium avium complex (MAC), in MAC-resistant A/J mice and MAC-susceptible C57 BL/6 mice. Cytokine mRNA expression was detected by polymerase chain reaction-assisted amplification of RNA extracted from the spleen cells of individual mice euthanized on days 0 to 40 of infection. By using this method, mRNAs for IL-2, IL-3, IL-5, IFN-α and IFN-β were not detected in RNA from the spleen cells of infected mice of both strains over the infection period. Expression of mRNAs for IL-1, IL-6, TNF-α and IFN-γ remained similar in intensity and timing between both mouse strains during infection. The mRNA for IL-4 was expressed in RNA from C57 BL/6 spleen cells after day 9, at the time when the number of viable M.intracellulare began increasing in the spleen of C57 BL/6 mice, while IL-4 mRNA was not induced in A/J spleen cells throughout the infectious course. Moreover, mRNA for IL-10 was expressed in C57 BL/6 mice at higher levels than that in A/J mice after day 6 of infection. Recombinant IL-4 and IL-10 affected anti-MAC activity of spleen cells from MAC-infected A/J mice in vitro, and also recombinant IL-4 suppressed the in vitro production of IFN-γ by infected A/J spleen cells upon stimulation with M.intracellulare extract. These results suggest that the induction of inhibitory cytokines, including IL-4 and IL-10, after MAC infection results in deterioration of mouse innate resistance to MAC infection.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.5 p.477-4860469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2932奈良医学雑誌, 46(5): 477-486http://hdl.handle.net/10564/2932http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2932/1/477-486p.%e3%83%9e%e3%82%a6%e3%82%b9Mycob%ce%b1cterium_intr%ce%b1cellulare%e6%84%9f%e6%9f%93.pdf04695550AN00180974奈良医学雑誌4654774861995-10-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29332017-05-29T06:08:49Zhdl_10564_1496特別養護老人ホーム新規入所者に対する精神医学的介護に関する縦断的研究PROSPECTIVE AND LONGITUDINAL STUDIES ON PSYCHIATRIC ISSUES OF NEWCOMER RESIDENTS IN A NURSING HOME三宅, 雅一nursing homebehavioral problemdementiaHasegawa's dementia rating scaleADLStudies on psychiatric issues of 244 consecutive new residents in a nursing home were made prospectively and longitudinally. Psychiatric diagnoses, psychotic symptoms, behavioral problems, score with Hasegawa's dementia rating scale, and activity of daily living (ADL) were investigated. The prevalence rate of dementia was 88.9% (Alzheimer type, 22.5% : vascular type, 45.5%). 77.9% of the total sample had psychotic symptoms, and 44.3% had behavioral problems. In cases of Alzheimer type dementia, the severity of dementia and the number of behavioral problems significantly increased with time course, while these did not change significantly in cases of vascular dementia.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.5 p.500-5150469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2933奈良医学雑誌, 46(5): 500-515http://hdl.handle.net/10564/2933http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2933/1/500-515p.%e7%89%b9%e5%88%a5%e9%a4%8a%e8%ad%b7%e8%80%81%e4%ba%ba%e3%83%9b%e3%83%bc%e3%83%a0%e6%96%b0%e8%a6%8f%e5%85%a5%e6%89%80%e8%80%85%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b.pdf04695550AN00180974奈良医学雑誌4655005151995-10-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29342017-05-29T06:08:59Zhdl_10564_1496皮膚電気活動、主観的気分変化、精神症状、治療効果に対する向精神薬の影響の研究 : 単回、点滴静注による試みA STUDY OF PSYCHOPHARMACA EFFECT ON ELECTRODERMAL ACTIVITY, SUBJECTIVE MOOD CHANGE, PSYCHOTIC SYMPTOMS AND RESULTS OF TREATMENT山岡, 一衛skin conductance level (SCL)subjective mood changepsychopharmacotherapyintravenousdrip injection (IVD)The aim of this study was to examine the possibility that skin conductance level (SCL) and a patient's subjective mood change during intravenous drip injection of psychopharmaca could predict the results of, or response to, phycopharmacotherapy. Sixty-six patients with depression, 42 with neurosis, 25 with schizophrenia and 8 with other psychiatric disorders were investigated on SCL, subjective mood change, and score of Brief Psychiatric Rating Scale (BPRS) during intravenous drip injection of sulpiride or other psychopharmaca. Improved subjective mood changes were significantly correlated to decreased SCL and were also significantly correlated to results of treatment in 1 month and 3 months. For depressive patients a criterion of SCL<4.0μS and improved subjective mood change might be a good predictor of favorable results of, or favorable response to, psychopharmacotherapy.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.5 p.516-5300469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2934奈良医学雑誌, 46(5): 516-530http://hdl.handle.net/10564/2934http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2934/1/516-530p.%e7%9a%ae%e8%86%9a%e9%9b%bb%e6%b0%97%e6%b4%bb%e5%8b%95%ef%bc%8c%e4%b8%bb%e8%a6%b3%e7%9a%84%e6%b0%97%e5%88%86%e5%a4%89%e5%8c%96%ef%bc%8c%e7%b2%be%e7%a5%9e%e7%97%87%e7%8a%b6%ef%bc%8c%e6%b2%bb%e7%99%82%e5%8a%b9%e6%9e%9c%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b.pdf04695550AN00180974奈良医学雑誌4655165301995-10-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29352017-05-29T06:08:59Zhdl_10564_1496精神分裂病における退屈についての一考察 (外的刺激に際しての反応並びに精神症状評価)A STUDY IN REGARD TO BOREDOM IN SCHIZOPHRENIA (REACTION UNDER EXTERNAL STIMULATION AND ASSESSMENT OF MENTAL SYMPTOMS)松岡, 出schizophreniaboredomHanshin EarthquakepsychopathologyPsychopathological aspects were studied through investigations of asking schizophrenic inpatients about their views related to boredom. Boredom has seldom been researched in spite of being an important phenomenon in understanding schizophrenia. This paper suggests that schizophrenic patients, especially chronic patients, are often satisfied with monotonous circumstances. External stimulus, even though unexpected, does not easily alter behaviour patterns.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.5 p.531-5370469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2935奈良医学雑誌, 46(5): 531-537http://hdl.handle.net/10564/2935http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2935/1/531-537p.%e7%b2%be%e7%a5%9e%e5%88%86%e8%a3%82%e7%97%85%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e9%80%80%e5%b1%88%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6%e3%81%ae%e4%b8%80%e8%80%83%e5%af%9f.pdf04695550AN00180974奈良医学雑誌4655315371995-10-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29362017-06-11T23:20:26Zhdl_10564_1496N-butyl-N-(4-hydroxybutyl) nitrosamineによるラット膀胱発癌における細胞増殖の解析ANALYSIS OF CELL PROLIFERATION IN RAT BLADDER CARCINOMA INDUCED BY N-BUTYL-N-(4-HYDROXYBUTYL) NITROSAMINE岡本, 新司bladder carcinomaN-butyl-N-(4-hydroxybutyl) nitrosamineflowcytometryproliferating cell nuclear antigenHistopathological examination, flowcytometry (FCM) study and proliferating cel1 nuclear antigen (PCNA) analysis were serially performed during the induction of carcinogenesis by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in the rat bladder, which is known to be an experimental model of human non-invasive papil1ary bladder cancer. Histological malignancy of the induced tumors was compared with the degree of cel1 proliferation by these three methods. FCM analysis revealed substantial differences of DNA change in bladder epithelial cel1s between the 4-week and 8-week treatment groups. These findings coincided with the changes observed in the histopathological examination concurrently performed. In the analysis of ploidies, tetraploid did not appear in the bladder of rats treated with BBN for 4 weeks. In PCNA analysis of epithelial cel1s in BBN-induced rat bladder carcinoma, PCNA-positive cel1sin the carcinoma increased with the severity of histopathological change. In addition, the PCNA index tended to be higher in the bladder of rats treated with BBN, which appeared to be histopathological1y normal. These findings suggest that the PCNA index serves as one useful parameter to predict the progression and proliferation of bladder carcinoma.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin Paper良医学雑誌 Vol.46 No.5 p.538-5500469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2936奈良医学雑誌, 46(5): 538-550http://hdl.handle.net/10564/2936http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2936/1/538-550p.N-butyl-N-%284-hydroxybutyl%29_nitrosamine%e3%81%ab%e3%82%88%e3%82%8b.pdf04695550AN00180974奈良医学雑誌4655385501995-10-31jpnpublisher