2024-03-29T05:23:12Zhttp://ginmu.naramed-u.ac.jp/dspace-oai/request
oai:ginmu.naramed-u.ac.jp:10564/8112017-06-11T23:20:26Zhdl_10564_1494表紙、目次、投稿規定、奥付(Vol.46 No.3)表紙目次投稿規定奥付奈良医学会2009-03-25T02:06:43Z2009-03-25T02:06:43Z1995-06-30OtherOthers255097 bytesapplication/pdf奈良医学雑誌 Vol.46 No.30469555013450069http://hdl.handle.net/10564/81104695550AN00180974奈良医学雑誌463jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/8122017-05-29T06:07:20Zhdl_10564_1494原発性両側乳癌の1例A CASE OF PRIMARY BILATERAL BREAST CARCINOMA楯川, 幸弘中谷, 勝紀朴, 秀一石井, 久史笠松, 稔中野, 博重bilateral breast carcinomaoncogenetumor suppresor geneA 49-year-old female who had noticed hard tumors in bilateral breasts
visited our hospital. There were depression of nipples and Delle needle biopsy revealed
Group Ⅴ for both tumors. Bone scan showed abmormal accumulation in the sternum and
bilateral lower ribs. Bone metastasis was suspected. Auchincloss method was performed
for bilateral breasts simultaneously because of the advanced stage of cancers and suspected
bone metastasis. Histopathologically both lesions were diagnosed as primary bilateral
breast carcinoma. We examined hormone recepters, DNA ploidy, amplification of c-myc
and c-erbB-2 genes and loss of heterozygosity (LOH) of p 53 and chromosome 16 q, 17 p in
bilateral breast tissues. These results showed that the right breast tumor was estrogen
recepter-positive, progesteron recepter-negative and of DNA diploidy pattern, while the left
breast tumor was estrogen recepter-positive, progesteron recepter-positive and of DNA
aneuploidy pattern. Amplification of c-myc and c-erbB-2 and LOH of p 53 and chromosome
16 q, 17 p were not detected in both lesions.奈良医学会2009-03-25T02:16:56Z2009-03-25T02:16:56Z1995-06-30ArticleDepartmental Bulletin Paper1291679 bytesapplication/pdf奈良医学雑誌 Vol.46 No.3 p.161-1660469555013450069http://hdl.handle.net/10564/81204695550AN00180974奈良医学雑誌463161166jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/8132017-05-29T06:07:20Zhdl_10564_1494十二指腸乳頭部早期癌を伴う乳頭部腺腫の一例A CASE OF EARLY CANCER IN ADENOMA OF THE PAPILLA VATER石井, 禎暢森安, 博人喜多, 公雄松山, 義則吉川, 高志松本, 昌美坂口, 嘉一帆風, 洋一梅本, 典江水本, 靖士福井, 博辻井, 正堤, 雅弘小西, 陽一papilla Vaterearly canceradenomaendscopic ultrasonographyWe report a rare case of early cancer in adenoma of the papilla Vater. An
81-year-old male was referred to our hospital for the purpose of close examination of
jaundice. Abdominal echography and computed tomography revealed slight dilatation of
the intrahepatic and common bile duct without any tumors or stones. Hypotonic duodeno-
graphy and endoscopic examination showed the swelling of papilla Vater with irregularity
and erosion of the surface. The biopsy specimen of the lesion was adenoma partially
involved by spindle-shaped atypical epithelial cells with large chromation, suggesting the
existence of adenocarcinoma. ERCP findings exhibited a defect shadow in the distal end of
the common bile duct and slight dilatation of the main pancreatic duct. Endoscopic
ultrasonography (EUS) showed a smooth swelling of papilla Vater, 25×13 mm in size, but
no invasion into the surrounding tissues. Pancreatoduodenectomy was performed. His-
tological diagnosis of the resected specimen was adenocarcinoma in adenoma of the papilla
Vater, that stayed in the mucosal layer.奈良医学会2009-03-25T02:29:42Z2009-03-25T02:29:42Z1995-06-30ArticleDepartmental Bulletin Paper3387408 bytesapplication/pdf奈良医学雑誌 Vol.46 No.3 p.167-1750469555013450069http://hdl.handle.net/10564/81304695550AN00180974奈良医学雑誌463167175jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/8142017-05-29T06:07:20Zhdl_10564_1494当院における腹腔鏡下胆嚢摘出術の検討AN ANALYSIS OF OUR CASES WITH LAPAROSCOPIC CHOLECYSTECTOMY庄, 雅之今川, 敦史細井, 孝純山本, 雅敏藤本, 平祐八倉, 萬之助松田, 雅彦中野, 博重laparoscopic cholecystectomycholecystolithiasiscarcinoma of the gallbladderWe performed laparoscopic cholecystectomy on 183 patients from August
1991 to December 1994. These patients, 66 men and 117 women, had a mean age of 51.4
years (range : 21-81). One hundred seventy-seven patients (96.7 %) had successful comple-
tion of the laparoscopic cholecystectomy. Six patients (3.3 %) required conversion to open
cholecystectomy because of bile duct injury in three patients, vascular injury of the
mesenterium in one patients, massive subcutaneous emphysema in one patient and a lot of
gallstones falling into the peritoneal cavity in one patient. All perioperative complications
were not fatal. The mean postoperative hospital stay of patients undergoing laparoscopic
cholecystectomy was 7.3 days. It was significantly shorter than the 19.5 days of the 39
patients undergoing open cholecystectomy in the same period. Laparoscopic cholecys-
tectomy is an effective procedure, improving the quality of life of the patients. With the
improvement and spread of endoscopic surgery, indications for that are expected to
increase in the future. But it is important to discuss fully and be circumspect in extending
the indications.奈良医学会2009-03-25T04:00:55Z2009-03-25T04:00:55Z1995-06-30ArticleDepartmental Bulletin Paper575807 bytesapplication/pdf奈良医学雑誌 Vol.46 No.3 p.176-1800469555013450069http://hdl.handle.net/10564/81404695550AN00180974奈良医学雑誌463176180jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/8152017-05-29T06:07:20Zhdl_10564_1494動脈硬化性血管障害患者の尿中微量蛋白排泄量URINARY EXCRETION OF MICROPROTEINS AND ATHEROSCLEROTIC VASCULAR COMPLICATIONS金内, 雅夫西岡, 久之赤井, 真弓紀川, 伊敏川野, 貴弘中島, 靖夫橋本, 俊雄土肥, 和紘atherosclerosis obliteranceα1-microglobulinβ2-microglobulincerebrovascular diseaseischemic heart diseaseN-acetyl-β-D-glucosaminidaseurinary albuminUrinary excretion of microproteins was evaluated at different ages in
patients with atherosclerotic vascular complications including ischemic heart disease,
cerebrovascular disease and atherosclerosis obliterance. Two hundred-five patients (148
males and 57 females) ranging from 40 to 79 years of age were divided into the 4 age groups
in each gender ; 40s, 50s, 60s and 70s, respectively. Patients with overt proteinuria or with
a serum creatinine level above normal limits were excluded from the study. Diabetes
mellitus and severe hypertensive cases were also excluded. Urinary albumin excretion was
significantly increased only in the 70s group as compared with the 50s and 60s groups in
males, but was similar in each age group in females. There was no difference in albumin
excretion between males and females. Urinary excretions of α1-microglobulin , β2-
microglobulin and N-acetyl-β-D-glucosaminidase were not changed with age, and no signifi-
cant difference in these parameters was found between the genders. Serum creatinine level
showed no change with increasing age. Both urinary excretion of creatinine and values of
creatinine clearance showed atendency to decrease with increasing age. These data suggest
that urinary excretion of microproteins is not influenced by aging and gender in patients
with atherosclerotic vascular complications.奈良医学会2009-03-25T04:12:44Z2009-03-25T04:12:44Z1995-06-30ArticleDepartmental Bulletin Paper889223 bytesapplication/pdf奈良医学雑誌 Vol.46 No.3 p.181-1870469555013450069http://hdl.handle.net/10564/81504695550AN00180974奈良医学雑誌463181187jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/8162017-06-11T23:20:26Zhdl_10564_1494腫瘤形成性石灰化(tumoral calcinosis)が透析膜の変更によって消失した維持透析患者の1例A CASE OF IMPROVED TUMORAL CALCINOSIS AFTER SWITCHING OF A DIALYSIS MEMBRANE山口, 透平山, 俊英平田, 英二岩野, 正之赤井, 靖宏浜口, 尚重土肥, 和紘biocompatibilityhemodialysisinterleukin-6 (IL-6)polymethyl methacrylate (PMMA)regenerated cellulose (RC)tumoral calcinosisWe report a case of improved tumoral calcinosis after switching of a
dialysis membrane. A 54-year-old female on maintenance dialysis therapy using polymethyl
methacrylate (PMMA) membrane was found to have painless masses on the left side of the
anterior cervical resion, pubic symphysis, and dorsum pedis in January, 1990. These masses
were diagnosed as tumoral calcinosis by X-ray. Interleukin-6 (IL-6), a multifunctional
cytokine, is considered to be responsible for acute and chronic complications, such as
dialysis disequilibrium syndrome and dialysis amyloidosis observed in patients on
hemodialysis.
Then, we measured serum IL-6 of this patient to evaluate biocompatibility of the
hemodialysis membrane. This patient showed a higher level of serum IL-6 (140 pg/ml) in
post-dialysis compared with that in pre-dialysis (90 pg/ml). Therfore, PMMA membrane
was thought to be unsuitable for dialysis therapy in this patient. After switching to
regenerated cellulose (RC) membrane in September, 1990, serum IL-6 level decreased
rapidly (48 pg/ml) in post-dialysis. Tumoral calcinosis observed in the left side of the
anterior cervical region, pubic symphysis, and dorsum pedis almost disappeared 15 months
later. This case suggests that serum IL-6 is useful for evaluating biocompatibility of the
hemodialysis (HD) membrane.奈良医学会2009-03-25T04:23:42Z2009-03-25T04:23:42Z1995-06-30ArticleDepartmental Bulletin Paper1863500 bytesapplication/pdf奈良医学雑誌 Vol.46 No.3 p.188-1940469555013450069http://hdl.handle.net/10564/81604695550AN00180974奈良医学雑誌463188194jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/8172017-05-29T06:07:21Zhdl_10564_1494奈良県立医科大学泌尿器科学教室における1990年の臨床統計CLINICAL STATISTICS ON OUTPATIENTS, INPATIENTS AND OPERATIONS IN THE DEPARTMENT OF UROLOGY, NARA MEDICAL UNIVERSITY, 1990高島, 健次岡島, 英五郎平尾, 佳彦大園, 誠一郎三馬, 省二金子, 佳照松木, 尚百瀬, 均岩井, 哲郎吉江, 貫植村, 天受田畑, 尚一藤本, 清秀田中, 宣道平山, 暁秀安川, 元信田中, 洋造永吉, 純一堀川, 直樹米田, 龍生clinical statisticsurological clinic1990Clinical statistics in 1990 on outpatients, inpatients and operations in the
Department of Urology, Nara Medical University, are reported in this paper. The total
number of outpatients was 3,645 and inpatients numbered 343. Among these inpatients,
urological tumors were most frequent (178 cases, 51.9 %), followed by urolithiasis (57
cases, 16.6 %), renal failure (43 cases, 12.5 %), and others. Totally 444 operations were
performed.奈良医学会2009-03-25T04:37:38Z2009-03-25T04:37:38Z1995-06-30ArticleDepartmental Bulletin Paper663571 bytesapplication/pdf奈良医学雑誌 Vol.46 No.3 p.195-2010469555013450069http://hdl.handle.net/10564/81704695550AN00180974奈良医学雑誌463195201jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/8182017-05-29T06:07:20Zhdl_10564_1494奈良県立医科大学泌尿器科学教室における1991年の臨床統計CLINICAL STATISTICS ON OUTPATIENTS, INPATIENTS AND OPERATIONS IN THE DEPARTMENT OF UROLOGY, NARA MEDICAL UNIVERSITY, 1991米田, 龍生堀川, 直樹岡島, 英五郎平尾, 佳彦大園, 誠一郎三馬, 省二吉田, 克法金子, 佳照百瀬, 均岩井, 哲郎植村, 天受田畑, 尚一林, 美樹森田, 昇藤本, 清秀平山, 暁秀田中, 洋造永吉, 純一木村, 昇紀雄谷, 剛士clinical statisticsurological clinic1991Clinical statistics in 1991 on outpatients, inpatients and operations in the
Department of Urology, Nara Medical University, are reported in this paper. The total
number of outpatients was 3,457, and inpatients numbered 310. Among these inpatients,
urological tumors were most frequent (174 cases, 56.1 %), followed by renal failure (45
cases, 14.2 %), urolithiasis (27 cases, 8.7 %), and others. Totally 361 operations were
performed.奈良医学会2009-03-25T04:50:19Z2009-03-25T04:50:19Z1995-06-30ArticleDepartmental Bulletin Paper664215 bytesapplication/pdf奈良医学雑誌 Vol.46 No.3 p.202-2080469555013450069http://hdl.handle.net/10564/81804695550AN00180974奈良医学雑誌463202208jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/8192017-05-29T06:07:24Zhdl_10564_1494奈良県立医科大学泌尿器科学教室における1992年の臨床統計CLINICAL STATISTICS ON OUTPATIENTS, INPATIENTS AND OPERATIONS IN THE DEPARTMENT OF UROLOGY, NARA MEDICAL UNIVERSITY, 1992永吉, 純一田中, 洋造岡島, 英五郎平尾, 佳彦大園, 誠一郎三馬, 省二吉田, 克法岩井, 哲郎植村, 天受山本, 雅司林, 美樹森田, 昇吉川, 元祥坂宗, 久藤本, 清秀米田, 龍生木村, 昇紀雄谷, 剛士太田, 匡彦田中, 雅博谷, 満clinical statisticsurological clinic1992Clinical statistics in 1992 on outpatients, inpatients and operations in the
Department of Urology, Nara Medical University, are reported in this paper. The total
number of outpatients was 2,990, and inpatients numbered 336. Among these inpatients,
urological tumors were most frequent (146 cases, 43 %), followed by renal failure (51 cases,
15 %), urolithiasis (44 cases, 13 %) and others. Totally 345 operations were performed.奈良医学会2009-03-25T05:05:37Z2009-03-25T05:05:37Z1995-06-30ArticleDepartmental Bulletin Paper650530 bytesapplication/pdf奈良医学雑誌 Vol.46 No.3 p.209-2150469555013450069http://hdl.handle.net/10564/81904695550AN00180974奈良医学雑誌463209215jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/8202017-05-29T06:07:25Zhdl_10564_1494奈良県立医科大学泌尿器科学教室における1993年の臨床統計CLINICAL STATISTICS ON OUTPATIENTS, INPATIENTS AND OPERATIONS IN THE DEPARTMENT OF UROLOGY, NARA MEDICAL UNIVERSITY, 1993木村, 昇紀雄谷, 剛士岡島, 英五郎平尾, 佳彦大園, 誠一郎三馬, 省二吉田, 克法百瀬, 均植村, 天受坂, 宗久二見, 孝妻谷, 憲一黒岡, 公雄藤本, 清秀米田, 龍生清水, 一宏clinical statisticsurological clinic1993Clinical statistics in 1993 on outpatients, inpatients and operations in the
Department of Urology, Nara Medical University, are reported in this paper. The total
number of outpatients was 2,785 and inpatients numbered 329. Among these inpatients,
urological tumors were most frequent (148 cases, 44.7 %), followed by renal failure (74
cases, 22.5 %), urolithiasis (36 cases, 10.9 %), and others. Totally 320 operations were
performed.奈良医学会2009-03-26T00:17:39Z2009-03-26T00:17:39Z1995-06-30ArticleDepartmental Bulletin Paper648582 bytesapplication/pdf奈良医学雑誌 Vol.46 No.3 p.216-2220469555013450069http://hdl.handle.net/10564/82004695550AN00180974奈良医学雑誌463216222jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/8212017-05-29T06:07:25Zhdl_10564_1494ラット上頸神経節節前細胞の脊髄内局在および大きさについてLOCALIZATION AND SIZE OF PREGANGLIONIC SYMPATHETIC NEURONS IN THE RAT SPINAL CORD SUPPLYING TO THE SUPERIOR CERVICAL GANGLION森本, 佳成匠原, 悦雄杉村, 正仁spinal cordsympathetic neuronsensory neuronhorseradish peroxidase (HRP)We investigated localization and size of preganglionic neurons in the spinal
cord supplying to the superior cervical ganglion (SCG) by using horseradish peroxidase
(HRP) method. We also payed attention to possibility of interganglionic projection from
the contralateral SCG, the stellete (SG) or the trigeminal ganglia (TRG).
40 % HRP (1μl) was injected into the SCG of anesthetized Wistar rats. After 48-hour
survival period, animals were perfused with fixative and the spinal cord, SCG and SG were
dissected out, sectioned and processed with tetramethyl benzidine method. Neutral red
solutions was employed as counterstain.
Labeled cells were recognized only at the ipsilateral side to the HRP application and were
restricted to the spinal segments C₈-T₅. More than 70 % of them were located in T₁-T₂
segments (Table 1). They were localized in three regions of the spinal cord ; the inter-
mediolateral nucleus (IML : 91.7 %), lateral funiculus (LF : 8.0 %o) and intercalated region
(IC : 0.3 %), but no labeled cells in the central autonomic nucleus (CA) (Table 2). Labeled
cells were small ; their mean diameter was 12.3±2.0μm. No labeled cells existed in the
contralateral SCG, or bilateral SG or TRG.
These results suggest that most of preganglic neurons projecting to SCG localize in IML of
the spinal segment T₁, T₂. No trigeminal sensory neurons are directly blocked by cervical
sympathetic block, because of trigeminal fibers not projecting to SCG. There are no
innervating fibers from SCG of the contralateral side or SG.奈良医学会2009-03-26T00:30:57Z2009-03-26T00:30:57Z1995-06-30ArticleDepartmental Bulletin Paper1140047 bytesapplication/pdf奈良医学雑誌 Vol.46 No.3 p.223-2270469555013450069http://hdl.handle.net/10564/82104695550AN00180974奈良医学雑誌463223227jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/8222017-05-29T06:07:23Zhdl_10564_1494好酸球における活性化抗原CD69の発現EXPRESSION OF ACTIVATION ANTIGEN CD69 ON EOSINOPHILS森井, 武志bronchoalveolar lavage fluidCD69eosinophilspleural effusionThe activation antigen, CD69, has been shown to be expressed on activated
lymphocytes. CD69 has also been shown to be associated with the signal transduction
process. In this study, the author performed flowcytometric analysis of CD69 expression on
eosinophils obtained from the bronchoalveolar lavage fluid (BALF), pleural effusion, or
peripheral blood (PB) of various patients. Whatever the diseases were, lung eosinophils
obtained from BALF or pleural effusion expressed significant levels of CD69, whereas most
PB eosinophils did not express CD69. Further, CD69 expression was induced on PB
eosinophils by the activation of interleukin-3 (IL-3), IL-5, granulocyte macrophage colony
stimulating factor (GM-CSF), interferon-a (IFN-α) and phorbol myristate acetate (PMA),
but platelet activating factor (PAF) did not induce CD69 expression. CD69 expression
induced by IL-3 or GM-CSF was in a dose and time dependent manner. The expression
could be induced significantly at low concentration of 10 pg/ml and was detected after
stimulation for two hours. These findings suggest that CD69 expressions are restricted to
local eosinophils, and that local eosinophils may stand at a different activating state from
PB eosinophils.奈良医学会2009-03-26T00:58:55Z2009-03-26T00:58:55Z1995-06-30ArticleDepartmental Bulletin Paper1351189 bytesapplication/pdf奈良医学雑誌 Vol.46 No.3 p.228-2400469555013450069http://hdl.handle.net/10564/82204695550AN00180974奈良医学雑誌463228240jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/8232017-06-11T23:20:26Zhdl_10564_1494担癌マウスにおける腫瘍の発育, 生存, 血中リンパ球サブセットに及ぼす脾摘の影響EFFECT OF SPLENECTOMY ON TUMOR GROWTH, SURVIVAL, AND BLOOD LYMPHOCYTE SUBSETS IN TUMOR BEARING MICE渡邉, 巌tumor bearing micecolon 26splenectomylymphocyte subsetsThe spleen is the largest peripheral lymphoid tissue and plays an important
role as one of the immune associated organs, but the effect of splenectomy in cancer therapy
remains obscure. The tumor growth, host survival, and the change of T-lymphocyte subsets
(Lyt2⁺, L3 T4⁺) in blood and spleen were studied using tumor bearing mice (Colon 26
bearing BALB/c mice) to investigate the effect of splenectomy, and the following results
were obtained.
1. In cotrol group (CONT), the subcutaneous mass appeared macroscopically in the 8th
day after tumor inoculation (Colon 26,2×10⁴), and started to death on the 30th day. Lyt2⁺
and L3 T4⁺ ratio of spleen elevated to the highest level on the 6th day and returned to the
same level with tumor growth, on the other hand, Lyt2⁺ ratio of blood kept constant
regardless of tumor growth, and L3 T4⁺ ratio dropped to the lowest level on the 9th day,
and returned to the same level with tumor growth.
2. When splenectomy was done on the 5th day after tumor inoculation (SPN 5 ; early
phase), Lyt2⁺ ratio of blood was significantly decreased (p<0.05) as compared with other
groups, and subsequent enhancement of tumor growth and the shortening of survival period
were observed (p<0.05).
3. On the 10th day after tumor inoculation (SPN 10 ; middle phase), Lyt2⁺ ratio of blood
was significantly elevated (p<0.05) as compared with other groups, and subsequent inhibition of tumor growth and elongation of survival period were observed.
4. On the 20th day after tumor inoculation (SPN 20 ; late phase), blood T-cell subsets did
not show great change, and subsequent enhancement of tumor growth and the shortening of
survival period were observed.
These results suggest that splenectomy of tumor bearing mice induces the change of
blood T-cell subsets, and affects the tumor growth and host survival ; early splencectomy
works tumor-enhancement, and middle splenectomy works tumor-inhibition ; also surgical
damage as well as late splenectomy works tumor-inhibition.奈良医学会2009-03-26T01:10:52Z2009-03-26T01:10:52Z1995-06-30ArticleDepartmental Bulletin Paper911259 bytesapplication/pdf奈良医学雑誌 Vol.46 No.3 p.241-2500469555013450069http://hdl.handle.net/10564/82304695550AN00180974奈良医学雑誌463241250jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/8242017-06-11T23:20:26Zhdl_10564_1494DENTATORUBRAL-PALLIDOLUYSIAN ATROPHY (DRPLA) AND MIDLATENCY AUDITORY EVOKED RESPONSESKishimoto, ToshifumiHigashiura, NaotoHiraoka, YukieSakiyama, ShinobuKirita, IkuhiroNoriyama, YoshinobuItoh, NaotoUeda, AtsushiOribe, HiroakiIkawa, Genromidlatency auditory evoked responsesDRPLAmolecular diagnosisP1 abnormalityThe human 'P1' middle latency evoked potential is postulated to be generat-
ed in the thalamus by a cholinergic component of the ascending reticular activating system.
To test the midbrain function of dentatorubral-pallidoluysian atrophy (DRPLA), recording
of middle latency response to click stimuli were carried out in a DRPLA family which was
detected with the aid of molecular diagnosis. Comparisons between the DRPLA members
and the normal members indicated normal Pa responses but P1 component is abnormal in
DRPLA. This P1 abnormality suggests that the midbrain cholinergic cells in DRPLA may
be dysfunctional.奈良医学会2009-03-26T01:28:18Z2009-03-26T01:28:18Z1995-06-30ArticleDepartmental Bulletin Paper1097165 bytesapplication/pdf奈良医学雑誌 Vol.46 No.3 p.251-2580469555013450069http://hdl.handle.net/10564/82404695550AN00180974奈良医学雑誌463251258engpublisher
oai:ginmu.naramed-u.ac.jp:10564/8252017-06-11T23:20:26Zhdl_10564_1494AUDITORY P300 EVENT-RELATED POTENTIALS AND MINI MENTAL STATE EXAMINATION PERFORMANCE IN DEMENTIA ; EFFECTS OF IDEBENONE AND VINPOCETINEKishimoto, ToshifumiHiraoka, YukieOribe, HiroakiInoue, MakotoUeda, AtsushiMatsuyama, MitsuharuInoue, YuichiroItoh, TakashiYoshitomi, KatsunariMiyagi, TetsuroMasuda, NobuakiTatsuda, HiroshiNakanishi, YasuoNegoro, HidekiIkawa, Genrovascular dementiaevent-related potentials (ERPs)IdebenoneVinpocetineOne group of twenty-one demented patients were administered Idebenone
90 mg/day for eight weeks, the other group of thirty-two demented patients were adminis-
tered Idebenone 90 mg/day plus Vinpocetine 15 mg/day for eight weeks. Mini Mental State
Examination (MMSE) was carried out and auditory event-related potentials (ERPs) were
recorded pre-treatment, after four weeks treatment and after eight weeks treatmet.
MMSE performance was significantly improved with treatment in both groups. Central
P300 latency was shortened in the group which was treated with Idebenone and Vinpocetine,
but not in the group which was treated with Idebenone alone. Based on the obtained results,
we were convinced that administration of Idebenone and Vinpocetine was very useful in the
treatment of vascular dementia.奈良医学会2009-03-26T01:47:10Z2009-03-26T01:47:10Z1995-06-30ArticleDepartmental Bulletin Paper891229 bytesapplication/pdf奈良医学雑誌 Vol.46 No.3 p.259-2660469555013450069http://hdl.handle.net/10564/82504695550AN00180974奈良医学雑誌463259266engpublisher